Perception and Reading in Aging and Alzheimer's Disease

衰老和阿尔茨海默病的感知和阅读

• 批准号: 6908756
• 负责人: GARRETT H. RIGGS
• 金额: $ 8.46万
• 依托单位: UNIVERSITY OF ROCHESTER
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-09-30 至 2010-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6908756
• 关键词: Alzheimer' s disease; age difference; behavioral /social science research tag; clinical research; human old age (65+); human subject; patient oriented research; psycholinguistics; reading disorder; visual perception; young adult human (21-34)

DESCRIPTION (provided by applicant): Reading is both visual and linguistic. Visual perceptual stimuli (letters, words, and sentences) first activate cerebral cortical visual networks, then language networks. Reading should therefore be studied using an interdisciplinary approach that accounts for both visual and linguistic processes. Models of reading and its disorders have included developmental dyslexia and lesion studies. While such models have unquestionably advanced understanding of reading, they are nonetheless limited: the pathophysiologic basis of developmental dyslexia is not known, acquired alexia is often accompanied by other neurologic deficits, and lesions are rarely identical across subjects. Alzheimer's disease (AD) is another potentially informative but under-characterized model of abnormal reading. The pathophysiology is known, the progression of pathology is relatively consistent across subjects, and the disease consistently affects areas known to be involved in reading and language (particularly the supramarginal and angular gyri). There is a wealth of data on language changes in AD, and difficulty communicating (including reading written reminders and treatment instructions) exacerbates disease burden for patients and caregivers. Whether this differs from healthy aging (and if so, how) is not known. Our laboratory has extensive experience characterizing visual perceptual changes in AD, and we have shown that visual perceptual changes in AD are quantitatively different from normal aging. We now propose using refined psychophysical and linguistic methods to quantitatively evaluate the contribution of visual perceptual abnormalities to reading disorders in AD. We hypothesize that higher order deficits of visuoperceptual and linguistic function interact to create a spectrum of reading impairments in aging and Alzheimer's disease. Our approach integrates visual perception and linguistics, and we will test our hypothesis in a series of experiments to quantify the contributions of both visual and linguistic deficits to reading impairment. Our goal is to develop a new paradigm for understanding reading disorders by unifying the psychophysical and linguistic perspectives. This will lead to new methods for early detection of reading disorders in aging and AD, the diagnosis of specific impairments, and guiding new therapies. The applicant's mentors have extensive complementary expertise to guide the research project. The career development plan will facilitate the applicant's transition to an independently funded researcher by the end of the award period.

描述（由申请人提供）：阅读既是视觉又是语言。视觉感知刺激（字母，单词和句子）首先激活脑皮质视觉网络，然后激活语言网络。因此，应使用跨学科方法来研究阅读，该方法涉及视觉和语言过程。 阅读模型及其疾病包括发育性阅读障碍和病变研究。尽管这种模型无疑具有对阅读的深入了解，但它们仍然有限：发育阅读障碍的病理生理基础尚不清楚，但获得的Alexia通常伴随着其他神经系统缺陷，并且病变在各个受试者之间很少相同。 阿尔茨海默氏病（AD）是另一个潜在的信息，但特征不足的异常阅读模型。病理生理学是已知的，病理学的进展相对一致，并且该疾病始终影响已知与阅读和语言有关的区域（尤其是上乳腺和角度的回旋）。关于AD的语言变化有很多数据，并且很难沟通（包括阅读书面提醒和治疗说明）加剧了患者和护理人员的疾病负担。这是否与健康的衰老有所不同（如果是这样，那么如何）。 我们的实验室具有广泛的AD视觉感知变化的经验，我们已经表明，AD的视觉感知变化在数量上与正常衰老有所不同。现在，我们建议使用精致的心理物理和语言方法定量评估视觉感知异常对AD阅读障碍的贡献。我们假设视觉观察和语言功能的高阶缺陷相互作用，以创造衰老和阿尔茨海默氏病的阅读障碍。我们的方法整合了视觉感知和语言学，我们将在一系列实验中检验我们的假设，以量化视觉和语言缺陷对阅读障碍的贡献。我们的目标是开发一个新的范式来理解阅读障碍 统一心理物理和语言观点。这将导致新的方法用于早期检测到衰老和AD中的阅读障碍，特定损伤的诊断以及指导新疗法。 申请人的导师具有广泛的互补专业知识来指导研究项目。职业发展计划将促进申请人在奖励期结束时向独立资助的研究人员的过渡。