DISRUPTED SPATIAL ORIENTATION IN ALZHEIMERS DISEASE

阿尔茨海默病的空间定向紊乱

• 批准号: 6339391
• 负责人: CHARLES J DUFFY
• 金额: $ 3.77万
• 依托单位: UNIVERSITY OF ROCHESTER
• 依托单位国家: 美国
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-08-01 至 2001-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6339391
• 关键词: biomedical resource; cognition; eye; nervous system

Patients who have suffered strokes affecting the right postenor parietal cortex often exhibit the syndrome of hemispatial neglect, an attentional deficit causing the individual to ignore the opposite side of the body and extrapersonal space. A common part of this syndrome is double simultaneous stimulus extinction (DSSE), wherein awareness of an object in contralateral hemispace is blocked only when a second object is simultaneously presented in the ipsilateral hemispace. We are exploring the mechanisms of visuospatial perception by testing patients with hemispatial neglect in a DSSE paradigm which uses overlying optic flow stimuli to trigger perceptual reorientation towards the neglected hemifield. The goal is to explore the dynamics of spatial orientation in subjects with various impairments of orientation attributable to lesions located in different parts of posterior parietal cortex. This project is operating as a collaboration between members of different units within the the University of Rochester Department of Neurology at Strong Memorial Hospital (Dr. Duffy from the Neuro-ophthalmology Unit and Dr. Langfitt from the Neuropsychology Unit). We are currently developing a separate limb of this study in collaboration with Dr. John G. Schmidt of St. Mary's Hospital Neurorehabilitation Unit in Rochester.

遭受中风的患者影响了正确的后期 顶叶皮质经常表现出半专业疏忽的综合征，这是 注意力赤字导致个人忽略另一侧 身体和人外空间。 该综合征的常见部分 是双重同时刺激灭绝（DSSE），其中意识 仅当第二秒时，对侧半间的物体被阻塞 物体同时显示在同侧半空间中。 我们 正在通过测试探索视觉空间感知的机制 使用DSSE范式中半部疏忽的患者 上覆盖的光流刺激以触发感知重新定向 走向被忽视的半场。 目标是探索动态 具有各种损害的受试者的空间取向 定向归因于位于不同部位的病变 后顶叶皮层。 这个项目作为一个 不同单位成员之间的协作 罗切斯特大学神经病学系强烈纪念 医院（Neuro-opthalmology单位的Duffy博士和博士 神经心理学部门的Langfitt）。 我们目前正在发展 与John G博士合作，本研究的一个单独肢体。 罗切斯特的圣玛丽医院神经居住部门的施密特。