A new master adaptor protein for Toll-like Receptor signalling

用于 Toll 样受体信号转导的新主接头蛋白

• 批准号: nhmrc : 1101072
• 负责人: Prof Jennifer Stow
• 金额: $ 59.81万
• 依托单位: The University of Queensland
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2016
• 资助国家: 澳大利亚
• 起止时间: 2016-01-01 至 2019-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/new-master-adaptor-receptor-signalling/662536
• 关键词: new; master; adaptor; protein; Toll

Certain proteins on the surface of cells are able to sense danger and infection. These receptors use adaptor proteins to enable cells to respond appropriately. We have discovered a new adaptor that controls receptor signalling in inflammation. This new master adaptor likely has widespread roles in infection and inflammation. We aim to understand how this adaptor works, and to identify ways of blocking its actions. These studies may help us to control inflammation underpinning many diseases.

细胞表面上的某些蛋白质能够感知危险和感染。这些受体使用衔接蛋白使细胞能够适当反应。我们发现了一个新的适配器，该适配器控制炎症中的受体信号传导。这个新的主适配器可能在感染和炎症中具有广泛的作用。我们旨在了解该适配器的工作原理，并确定阻止其行为的方法。这些研究可能有助于我们控制基于许多疾病的炎症。