Gut Absorption of Constrained Peptides for Local and Systemic Targeting

用于局部和全身靶向的限制肽的肠道吸收

• 批准号: LP210100101
• 负责人: Prof Jennifer Stow
• 金额: $ 50.22万
• 依托单位: The University of Queensland
• 依托单位国家: 澳大利亚
• 项目类别: Linkage Projects
• 财政年份: 2023
• 资助国家: 澳大利亚
• 起止时间: 2023-01-12 至 2026-01-11
• 项目状态: 未结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/LP210100101
• 关键词: Gut; Absorption; Constrained; Peptides; Local

Aims: This project aims to investigate how peptides are absorbed across the intestinal wall and distributed to organs and fluids in a rodent model by combining bio-analysis and pharmacokinetics with high-resolution microscopy and imaging. Significance: This project expects to generate the most comprehensive survey to date of the pathways and mechanisms of peptide absorption, biodistribution and immune cell targeting, by implementing innovative approaches. Expected Outcomes: Expected outcomes include significant new knowledge and a new multi-disciplinary platform for measuring peptide absorption. Benefits: This should provide significant benefits by informing the future design of peptides for supplements, therapeutics and carriers.

目的：该项目旨在通过将生物分析和药代动力学与高分辨率显微镜和成像相结合，研究肽如何通过啮齿动物模型的肠壁被吸收并分布到器官和体液中。 意义：该项目预计通过实施创新方法，对肽吸收、生物分布和免疫细胞靶向的途径和机制进行迄今为止最全面的调查。 预期成果：预期成果包括重要的新知识和用于测量肽吸收的新的多学科平台。 好处：这应该通过为补充剂、治疗剂和载体的肽的未来设计提供显着的好处。