Migration-Dependent Signalling in Macrophages

巨噬细胞中的迁移依赖性信号传导

• 批准号: DP230100504
• 负责人: Prof Jennifer Stow
• 金额: $ 45.1万
• 依托单位: The University of Queensland
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2023
• 资助国家: 澳大利亚
• 起止时间: 2023-05-17 至 2026-05-16
• 项目状态: 未结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP230100504
• 关键词: Migration; Dependent; Signalling; Macrophages

The project aims to investigate a mechanism of communication used by immune cells to guide each other towards sites of damage. The project will characterise newly revealed cell signalling membrane trails left behind by migrating cells, utilising biochemistry, innovative imaging and microscopy and a transparent zebrafish model to view cell migration through living tissues. Expected outcomes include new fundamental knowledge in the area of immune cell migration with relevance to the basic biology of inflammation, repair and regeneration and new innovations for cell imaging. Significant benefits are expected to arise from this new knowledge and from advanced skills training and improved national capabilities in bio-imaging and analysis.

该项目旨在研究免疫细胞用来引导彼此到达损伤部位的通信机制。该项目将利用生物化学、创新成像和显微镜以及透明斑马鱼模型来表征新发现的迁移细胞留下的细胞信号膜痕迹，以观察活组织中的细胞迁移。预期成果包括免疫细胞迁移领域与炎症、修复和再生基础生物学相关的新基础知识以及细胞成像的新创新。 预计这些新知识、高级技能培训以及提高的国家生物成像和分析能力将产生重大效益。