EPIDEMIOLOGY OF ARSENIC AND OTHER TOXIC METALS

砷和其他有毒金属的流行病学

• 批准号: 6106421
• 负责人: MARGARET Rita KARAGAS
• 金额: $ 15.82万
• 依托单位: DARTMOUTH COLLEGE
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-04-01 至 2000-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6106421
• 关键词: arsenic; biomarker; bladder neoplasm; cancer risk; chemical carcinogen; dosage; environmental contamination; environmental toxicology; heavy metals; human subject; neoplasm /cancer epidemiology; selenium; skin derivative; skin neoplasms; water pollution; water sampling /testing; water supply

We propose to investigate the potential risk of skin and bladder cancer associated with arsenic ingestion through contaminated drinking water in New Hampshire, and to evaluate alternative measures for quantifying individual exposure to toxic metals. Elevated concentrations of arsenic have been detected in drinking water supplies throughout the state of New Hampshire; approximately 5% of the private drinking water supplies contain arsenic levels above the current Safe Drinking Water Standards of 0.05 mg/L and 20% or more contain levels above the proposed standard of 0.002 mg/L. Therefore, we propose to expand our current state-wide case-control study of skin cancer (involving 600 basal cell and 300 squamous cell skin cancer cases and 600 population controls) to include; (1) an assessment of toxic metal concentrations in individual household drinking water supplies and (2) an added case group of 390 bladder cancer patients and 130 additional controls. Drinking water and blood samples drawn on case cases and controls will be used in studies exploring the biologic mechanisms involved in metal toxicity (e.g., genotoxicity in project #2). Analysis of toxic metal concentrations in household drinking water supplies will be performed in collaboration with the ICP-MS Core Facility. Our study will be among the first: (1) to quantify human exposure to arsenic on an individual level, using both biologic and drinking water assessments, and (2) to use these measures to examine the possible cancer risks associated with arsenic-containing drinking water for a geographically defined US population.

我们建议研究皮肤和膀胱癌的潜在风险 通过污染的饮用水与砷摄入有关 新罕布什尔州，并评估量化的替代措施 个人接触有毒金属。砷浓度升高 在整个新状态中都在饮用水供应中发现 汉普郡；大约5％的私人饮用水供应包含 砷含量高于目前的安全饮用水标准0.05 mg/l 和20％或以上的水平超过提议的0.002 mg/L的水平。 因此，我们建议扩大我们当前的全州病例对照研究 皮肤癌（涉及600个基础细胞和300个鳞状细胞皮肤癌 案件和600个人口控制）包括； （1）对有毒的评估 单个家庭饮用水供应中的金属浓度， （2）增加的390例膀胱癌患者和130例额外的病例组 控件。饮用水和血液样本在情况下抽取， 控件将用于探索涉及的生物学机制的研究 在金属毒性中（例如，项目＃2中的遗传毒性）。有毒分析 将执行家用饮用水中的金属浓度 与ICP-MS核心设施合作。我们的研究将在 第一个：（1）量化人类对人的砷的暴露 水平，使用生物学和饮用水评估，以及（2）使用 这些措施以检查与 含砷的饮用水，用于地理定义的我们 人口。