Cohort follow-up study of children exposed to arsenic in utero and early childhood

子宫内和幼儿期接触砷的儿童的队列随访研究

• 批准号: 9002844
• 负责人: ALLAN H SMITH
• 金额: $ 36.23万
• 依托单位: UNIVERSITY OF CALIFORNIA BERKELEY
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-05-16 至 2019-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9002844
• 关键词: Adolescent; Adult; Affect; Age; Arsenic; Attention; Bangladesh; Biological Markers; Blood Glucose; Blood Pressure; Body mass index; Cardiovascular Diseases; Cause of Death; Chemicals; Child; Childhood; Chile; Chronic; Chronic Disease; Chronic Kidney Failure; Clara cell; Cohort Studies; Creatinine; Data; Diabetes Mellitus; Environmental Exposure; Environmental Policy; Epidemiology; Exposure to; Fasting; Fetus; Future; Glycosuria; Health; Health Policy; Hemoglobin; Human; Incidence; Investigation; Kidney; Kidney Diseases; Knowledge; Laboratory Animals; Life; Lipids; Long-Term Effects; Longitudinal Studies; Lung; Lung diseases; Malignant Neoplasms; Malignant neoplasm of lung; Malignant neoplasm of urinary bladder; Measurement; Measures; Mothers; Myocardial Infarction; Outcome; Participant; Perinatal Exposure; Policies; Population; Proteins; Proteinuria; Public Health; Renal Glycosuria; Renal carcinoma; Renal function; Respiratory Signs and Symptoms; Respiratory physiology; Risk; Risk Factors; Serum; Shortness of Breath; Source; Spirometry; Surveillance Program; Toxic Environmental Substances; Water; Wheezing; aged; base; body system; cardiovascular disorder risk; cohort; deciduous tooth; diabetes risk; drinking water; early childhood; early life exposure; environmental chemical; environmental chemical exposure; experience; follow-up; human data; in utero; mortality; postnatal; potential biomarker; pregnant; prevent; public health priorities; success; toxicant; young adult

DESCRIPTION (provided by applicant): Little is known about the consequences of early life exposure to most common environmental chemicals, including arsenic. This constitutes a critical gap in knowledge, since our recent findings from Chile suggest that early life exposure to arsenic results in disturbing increases in young adult mortality from several cancers, including lung cancer, bladder cancer, kidney cancer, as well as non-cancer causes of death, including myocardial infarction, chronic renal failure and chronic respiratory disease. Arsenic is a remarkable toxicant already known to affect multiple organ systems in exposed adults, including increased incidence of several cancers, cardiovascular disease, chronic respiratory disease and diabetes. We have been following a cohort of 650 children in Bangladesh, approximately half of whom had a wide range of exposure to arsenic in drinking water in early life, up to 1000 μg/L, while the other half were never exposed to more than 10 μg/L in water. To date, our focus has been on respiratory disease, and we have found a marked increase in respiratory symptoms in the exposed children at ages 7-17 years, including wheezing and shortness of breath. We propose to continue following this unique cohort of children, not only to look for progression of respiratory disease, but also to add additional markers of early life effects for several other important chronic diseases. These include early markers and risk factors for cardiovascular disease (blood pressure, serum lipids, body mass index, and hemoglobin), diabetes (fasting blood sugar and glycosuria), and chronic renal effects (creatinine and serum ß2-microglobulin). We also plan a pilot investigation of arsenic in deciduous teeth as a biological marker for in utero and early childhood exposure. Studying the effects of early life arsenic exposure is a public health priority, since millions of pregnant mothers and children in the US and worldwide are exposed to arsenic in drinking water above the current drinking water standard of 10 μg/L. If further study confirms our preliminary evidence that early life exposure is important to the long-term health of exposed children, then much more attention must be paid to preventing early life arsenic exposure.

描述（由适用提供）：关于早期生命暴露于包括砷在内的最常见环境化学物质的后果知之甚少。这构成在Knowle中存在一个严重的差距，因为我们最近来自智利的发现表明，早期生命暴露于砷的早期暴露会导致几种癌症的年轻成人死亡率增加，包括肺癌，膀胱癌，肾脏癌以及非癌症原因，包括非癌症原因，包括心肌梗死，肾脏肾脏失败，慢性肾脏失败和慢性呼吸道疾病。砷是一种已经众所周知的一种显着的毒物，它会影响裸露的成年人的多个器官系统，包括多种癌症的发病率增加，心血管疾病，慢性呼吸道疾病和糖尿病。在孟加拉国，我们一直在追踪650名儿童的队列，其中大约一半在早期饮用水中暴露于砷的范围广泛，最多可达1000μg/l，而另一半则从未在水中暴露于10μg/l的水中。迄今为止，我们的重点一直在呼吸道疾病上，我们发现7-17岁的暴露儿童（包括Wheeling和呼吸急促）的呼吸道症状显着增加。我们建议继续跟随这种独特的儿童队列，不仅是寻找呼吸道疾病的进展，而且还为其他几种重要的慢性疾病增加了早期生命影响的其他标志。这些包括早期标记和心血管疾病（血压，血清脂质，体重指数和血红蛋白），糖尿病（空腹血糖和糖尿）以及慢性肾脏作用（肌酐和血清2-微球蛋白）的危险因素。我们还计划对落叶牙齿中的砷进行试点调查，作为子宫和幼儿暴露的生物标志物。研究早期砷暴露的影响是公共卫生的优先事项，因为美国和全世界的数百万孕妇和儿童在饮用水中暴露于目前10μg/l的饮用水标准。如果进一步的研究证实了我们的初步证据，即早期生命暴露对暴露儿童的长期健康很重要，那么必须给予更多关注以防止早期寿命暴露。