Arsenic and child respiratory health in Bangladesh

孟加拉国的砷与儿童呼吸系统健康

• 批准号: 7803738
• 负责人: ALLAN H SMITH
• 金额: $ 54.03万
• 依托单位: UNIVERSITY OF CALIFORNIA BERKELEY
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-05-01 至 2012-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7803738
• 关键词: Adolescent; Adult; Affect; Age; Air Pollutants; Arsenic; Bangladesh; Biomass; Breathing; Burn injury; Child; Childhood; Chile; Chronic; Coughing; Diet; Disease; Environmental Tobacco Smoke; Exposure to; Family; Family member; Future; Growth and Development function; Health; India; Individual; Indoor Air Pollution; Ingestion; Late Effects; Life; Lung; Lung diseases; Malignant neoplasm of lung; Measures; Methylation; Morbidity - disease rate; Nutritional; Nutritional status; Outcome; Perinatal Exposure; Population; Predisposition; Public Health; Respiratory physiology; Risk; Sampling; Shortness of Breath; Source; Symptoms; Time; Tube; Urine; Water; aged; cohort; comparison group; drinking water; lung development; mortality; respiratory; rural area; skin lesion

DESCRIPTION (provided by applicant): The lung is a surprisingly important target for the long term health effects of ingestion of inorganic arsenic in drinking water, but the impact of exposure during childhood is largely unknown. Children are likely to be especially susceptible since the development of the lung continues into childhood. In Chile, we have found that people who were exposed to arsenic in drinking water as children have 10-fold increased risks of lung cancer and chronic respiratory disease mortality when they become adults. In West Bengal, India we have found that adults with arsenic-caused skin lesions and high arsenic drinking water exposures have impaired lung function and increased rates of chronic respiratory disease. To date however, the impact of arsenic ingestion on lung function and respiratory health has not so far been studied in children. This application takes advantage of the fact that our collaborators in Bangladesh have examined 167,000 people for skin lesions and measured the arsenic concentrations in their drinking water. We plan to study 300 children aged 6-16 years living in the families having tube well water arsenic concentration mostly over 300 ug/L, and in which at least one member of the family has developed arsenic-related skin lesions. An unexposed comparison group of 300 children will be selected from families with no skin lesions, and whose water contains less than 50 ug/L. Lung function and respiratory symptoms, including chronic cough and shortness of breath, will be assessed in relation to current and past arsenic concentrations in all sources of drinking water throughout childhood, including in utero exposure. Potential susceptibility and interactions associated with indoor air pollution, diet, and nutritional status, will be investigated. Differences in susceptibility due to individual variability in the degree to which children metabolize arsenic to highly toxic methylated compounds identified in urine samples will also be assessed. The children in these exposed and unexposed families provide a unique opportunity to identify the effects of arsenic exposure during critical time periods of lung growth and development. The public health impact of adverse respiratory effects due to arsenic exposure in early life could be substantial given the large number of children exposed to arsenic in drinking water worldwide and the relevance of these outcomes for future population morbidity and mortality.

描述（由申请人提供）：肺部是饮用水中无机砷的长期健康影响的惊人重要目标，但是儿童期暴露的影响在很大程度上是未知的。由于肺部的发展一直持续到童年，因此儿童可能特别容易受到影响。在智利，我们发现，随着儿童的肺癌和慢性呼吸道疾病死亡的风险增加了10倍，他们成为成年人的饮用水中的人们。在印度西孟加拉邦，我们发现患有砷引起的皮肤病变和高砷饮用水暴露的成年人肺功能受损，慢性呼吸道疾病的发生率增加。然而，迄今为止，尚未在儿童中研究砷对肺功能和呼吸健康的影响。该应用程序利用了我们在孟加拉国的合作者检查了167,000人的皮肤病变，并测量了饮用水中的砷浓度。我们计划研究300名6-16岁的儿童，居住在具有管道水砷浓度的家庭中，主要超过300 ug/l，其中至少有一个家庭成员患有砷相关的皮肤病变。将从没有皮肤病变的家庭中选择一个未接触的300名儿童的比较组，其水的含量小于50 ug/l。肺功能和呼吸道症状，包括慢性咳嗽和呼吸急促，将根据整个童年的所有饮用水来源（包括子宫暴露）的当前和过去砷浓度进行评估。将研究与室内空气污染，饮食和营养状况相关的潜在敏感性以及相互作用。还将评估儿童代谢到尿液样品中鉴定出的高毒性甲基化化合物的敏感性差异。这些暴露和未暴露家庭的孩子提供了一个独特的机会，可以在肺部生长和发育的关键时期内确定砷暴露的影响。鉴于全世界遭受了大量儿童，由于砷在饮用水中暴露于砷的大量儿童以及这些结果与未来人口的发病率和死亡率的相关性，因此早期砷的不良呼吸影响对公共卫生的影响可能很大。