TRANSMISSION OF KAPOSIS SARCOMA & RETROPERITONEAL FIBROMATOSIS IN MACAQUES: AIDS

卡波济斯肉瘤的传播

• 批准号: 6116321
• 负责人: MARNIX L BOSCH
• 金额: $ 8.67万
• 依托单位: UNIVERSITY OF WASHINGTON
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-05-01 至 2000-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6116321
• 关键词: AIDS; Mammalia; Primates; gene therapy; immunology; infection; inflammation; lymphatic system; model design /development; neoplasm /cancer; virus

Kaposi's sarcoma is a neoplastic disease associated with AIDS, and retroperitoneal fibromatosis is a disease of macaques that is related to Kaposi's sarcoma. In this project we investigated infections of rhesus and cynomolgus macaques with retroperitoneal fibromatosis-associated herpesvirus (RFHV). Animals infected with RFHV showed signs of lymphoproliferative disease and developed an unusual proliferative arteriopathy. Transfer of RFHV into cynomolgus macaques resulted in a rapidly fatal myeloproliferative disorder characterized by circulating multinucleated giant cells. We also attempted to infect pigtailed macaques with Kaposi's sarcoma-associated herpesvirus, but were unable to demonstrate productive infection in these animals.

Kaposi的肉瘤是一种与艾滋病有关的肿瘤疾病，腹膜后纤维瘤病是一种与Kaposi的肉瘤有关的猕猴。 在这个项目中，我们研究了与腹膜后纤维瘤病相关的疱疹病毒（RFHV）的恒河猴和cynomolgus猕猴的感染。 感染RFHV的动物显示出淋巴增生性疾病的迹象，并产生了异常的增生性动脉炎。 将RFHV转移到Cynomolgus猕猴中，导致迅速致命的骨髓增生性疾病，其特征是循环多核巨细胞。 我们还试图用Kaposi与肉瘤相关的疱疹病毒感染锯齿状猕猴，但无法证明这些动物中的生产性感染。