INFECTION OF MACAQUE NEONATES W/ HIV 1 BY ORAL ADMINISTRATION

口服 HIV 1 型猕猴新生儿感染

• 批准号: 6116322
• 负责人: MARNIX L BOSCH
• 金额: $ 8.67万
• 依托单位: UNIVERSITY OF WASHINGTON
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-05-01 至 2000-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6116322
• 关键词: AIDS; Mammalia; Primates; immunology; infection; inflammation; lymphatic system; model design /development; virus

Receptive anal intercourse, but not orogenital sex, has been identified as a major risk factor for transmission of human immunodeficiency virus type I (HIV-1). In this study we inoculated newborn pigtailed macaques with HIV-1 via various mucosal routes. None of the animals inoculated orally became infected, whereas four of the five animals inoculated rectally did become infected. From this we conclude that oral inoculation is not as efficient as rectal inoculation in the transmission of HIV-1. On the other hand, the orally inoculated animals failed to thrive, indicating that perhaps HIV-1 did affect these animals in the absence of overt systemic infection.

接受性肛门性交，但不是植物性别，已被确定为传播人类免疫缺陷病毒I型（HIV-1）的主要危险因素。 在这项研究中，我们通过各种粘膜途径接种了新生儿型猕猴，并通过HIV-1接种。 接种口服的动物均未感染，而直肠接收的五只动物中的四只确实被感染了。 由此我们得出结论，口服接种不如HIV-1传播中直肠接种效率。 另一方面，口服接种动物未能繁殖，表明在没有明显的全身感染的情况下，HIV-1确实会影响这些动物。