MULTIPHOTON DOSE DERIVATION

多光子剂量推导

• 批准号: 6206153
• 负责人: JENNIFER A NICHOLS
• 金额: $ 2.01万
• 依托单位: CORNELL UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-09-01 至 2000-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6206153
• 关键词: bioengineering /biomedical engineering; biological products; biomedical resource; lasers; technology /technique

During the previous year we have completed the measurement of the two-photon action cross section for Photofrin and have begun additional measurements for other photosensitizing compounds. Under typical imaging conditions, Photofrin is observed to change from one-photon to two-photon excitation as the excitation wavelength is varied from 700-750 nm. This has been verified by measuring the edge response from a solution of Photofrin dissolved in methanol as a function of wavelength. For wavelengths between 750 and 980 nm the two-photon action cross section decreases from approximately 0.6 GM to 0.2 GM. Both absolute and relative cross section measurements have been made and found to agree. The two-photon excitation cross section of other photosensitizers are at various stages of completion and described and accounted for elsewhere.

去年我们完成了 Photofrin 的双光子作用截面已经开始 其他光敏化合物的额外测量。 在下面 典型的成像条件下，观察到 Photofrin 的变化 单光子到双光子激发，激发波长为 波长范围为 700-750 nm。 这已通过测量边缘得到验证 Photofrin 溶解在甲醇中的溶液作为响应 波长的函数。 对于 750 至 980 nm 之间的波长 双光子作用截面从大约 0.6 GM 减小到 0.2 通用汽车。 绝对和相对横截面测量都有 已制定并被发现同意。 双光子激发截面 其他光敏剂正处于不同的完成阶段 在别处描述和解释。