ECHOCARDIOGRAPHY WORKSTATION FOR ANIMAL RESEARCH

用于动物研究的超声心动图工作站

• 批准号: 2804033
• 负责人: MARIANN R PIANO
• 金额: $ 20.7万
• 依托单位: UNIVERSITY OF ILLINOIS AT CHICAGO
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-04-15 至 2000-04-14
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2804033
• 关键词: bioimaging /biomedical imaging; biomedical equipment; biomedical equipment purchase; echocardiography; heart imaging /visualization /scanning

A group of multidisciplinary researchers are requesting funds for the acquisition of an ultrasound imaging system (Acuson Sequoia [model C256]) to obtain echocardiograms in small animal models. Echocardiography or ultrasound imaging is a noninvasive method for the in situ measurement of cardiac anatomy and function. Collectively, but with separate National Institutes of Health supported research programs, this multidisciplinary group will use rat and murine transgenic models to examine changes in cardiac structure and function that are associated with normal, as well as pathological cardiovascular conditions. M-mode directed, two-dimensional directed and pulse wave Doppler echocardiographic recordings will be used to obtain information on cardiac anatomy and function. Altogether, eight major users will be utilizing the echocardiography system. The availability of such a machine and central location (Biological Resource Laboratory) will greatly enhance the research productivity of the participants in this grant proposal. In addition, because of the ability to make serial measurements in one animal, the number of sacrificed animals per protocol will decrease. Approximately 60 percent of the instrument time will be devoted to the research of Drs. Piano (PI), Buttrick (PI) and Solaro (PI), all of whom are primary investigators on existing NIH grants. The remaining 40 percent of the echocardiography imaging system time will be utilized by Drs. Geenen, Hickson, Arteaga, Varga, and Schwertz. The echocardiography workstation will be operated under the direction of Drs. Peter Varga, pediatric cardiologist, and Taylor Bennet. Long term maintenance will be the responsibility of the Biologic Resources Laboratory under the direction of Dr. Taylor Bennet. Director Bennet has appointed an advisory committee to set operation guidelines and user fees. In conclusion, the University of Illinois at Chicago has no echocardiography machine with a high frequency transducer available for animal research. A group of multidisciplinary researchers will use this system only for small animal research in their rat and murine models.

一组跨学科研究人员要求获得资金以获取超声成像系统（Acuson Sequoia [Model C256]），以在小动物模型中获得超声心动图。超声心动图或超声成像是一种原位测量心脏解剖和功能的无创方法。总的来说，但是，在单独的国家卫生研究院支持的研究计划的情况下，该多学科群体将使用大鼠和鼠类转基因模型来检查与正常以及病理心血管疾病相关的心脏结构和功能的变化。 M模式定向，二维定向和脉搏多普勒超声心动图记录将用于获取有关心脏解剖和功能的信息。 总之，八个主要用户将使用超声心动图系统。 这样的机器和中央位置（生物资源实验室）的可用性将大大提高参与者的研究生产力。 此外，由于能够在一种动物中进行连续测量，因此每个方案牺牲的动物数量将减少。大约60％的仪器时间将专门研究DRS的研究。钢琴（PI），Buttrick（PI）和Solaro（PI），他们都是现有NIH赠款的主要研究人员。 其余40％的超声心动图成像系统时间将由DRS使用。 Geenen，Hickson，Arteaga，Varga和Schwertz。 超声心动图工作站将在DRS的指导下进行操作。彼得·瓦尔加（Peter Varga），儿科心脏病专家和泰勒·贝内特（Taylor Bennet）。 长期维护将是泰勒·本内特（Taylor Bennet）博士的指导下的生物资源实验室的责任。 董事Bennet任命了一个咨询委员会来设定运营指南和用户费用。 总之，芝加哥伊利诺伊大学没有超声心动图机，具有可用于动物研究的高频传感器。 一组跨学科研究人员只会在其大鼠和鼠模型中使用该系统进行小型动物研究。