CORE--CLINICAL

核心--临床

• 批准号: 6315628
• 负责人: NORMAN LOUIS FOSTER
• 金额: $ 22.35万
• 依托单位: UNIVERSITY OF MICHIGAN AT ANN ARBOR
• 依托单位国家: 美国
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-06-01 至 2001-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6315628
• 关键词: Alzheimer's disease; aging; biomedical facility; brain disorder diagnosis; caregivers; clinical research; dementia; disease /disorder classification; health services research tag; human data; human subject; longitudinal human study; medical outreach /case finding; medical records; nervous system disorder epidemiology; neuropathology; neuropsychological tests; pathologic process; patient /disease registry; positron emission tomography; postmortem; psychomotor function; social support network; telecommunications

The Clinical Core promotes the goals of the MADRC and s3erves individual projects by recruiting patients for clinical research studies. Patients with Alzheimer' s disease and Alzheimer's mimics are identified at the University of Michigan with the help of collaborators in the Neurology and Geropsychiatry Clinics and the Neuropsychology Division and at Satellite Diagnostic and Treatment Centers located in Detroit and in rural Northern Michigan. This provides an ethnically diverse research population including rural and urban residing subjects reflecting the full range of disease severity from minimally symptomatic to severely impaired. Recruitment of normal control subjects is coordinated with the Human Subjects Core of the Pepper Older Americans Independence Center at the University of Michigan. Potential research subjects receive exclusion criteria. Demographic and caregiver data, dementia severity, neuropsychological performance, motor signs and behavior are characterized using standardized procedures. A subset of these patients who have named a health care advocate and are given provisional consent for an autopsy, and a cohort of normal individuals who have consented to an autopsy are periodically reassessed and serve as a resource for studies examining the clinical course of dementing disorders and clinico-pathological correlations Nurses and social workers help recruit patients to research studies and provide patient and caregiver support and telephone contacts that encourage research participation and the cooperation of families in obtaining postmortem brain examinations. They assure appropriate subject selection and patient safety by coordinating participation in multiple studies. The Clinical Core provides consultation about clinical aspects of dementia to investigators and other Cores and plays a major role in educational and outreach activities of the Center. It promotes collaboration with other Alzheimer Disease Centers for datasharing and joint projects such as the Alzheimer Disease Cooperative Study. Data collected are linked to ongoing epidemiological studies of aging at the University of Michigan including the Assets and Health Dynamics Study of community dwelling elderly and the National Nursing Home Resident Assessment Instrument for elderly receiving institutional care.

临床核心促进 MADRC 的目标，并通过招募患者进行临床研究来服务各个项目。密歇根大学在神经病学和老年精神病学诊所、神经心理学部门以及位于底特律和北密歇根农村的卫星诊断和治疗中心的合作者的帮助下，识别出患有阿尔茨海默病和类似阿尔茨海默病的患者。这提供了包括农村和城市居住受试者在内的种族多样化的研究人群，反映了从轻微症状到严重受损的各种疾病严重程度。正常对照受试者的招募是与密歇根大学佩珀美国老年人独立中心的人类受试者核心协调进行的。潜在的研究对象接受排除标准。使用标准化程序对人口统计和护理人员数据、痴呆严重程度、神经心理学表现、运动体征和行为进行表征。这些患者中的一部分指定了医疗保健倡导者并获得了尸检的临时同意，而一组同意尸检的正常人会定期重新评估，并作为检查痴呆症临床过程的研究资源护士和社会工作者帮助招募患者参与研究，并为患者和护理人员提供支持和电话联系，以鼓励研究参与以及家属在进行死后脑部检查时的合作。他们通过协调多项研究的参与来确保适当的受试者选择和患者安全。临床核心向研究人员和其他核心提供有关痴呆症临床方面的咨询，并在中心的教育和外展活动中发挥重要作用。它促进与其他阿尔茨海默病中心的数据共享和联合项目（例如阿尔茨海默病合作研究）的合作。收集的数据与密歇根大学正在进行的老龄化流行病学研究相关，包括社区居住老年人的资产和健康动态研究以及针对接受机构护理的老年人的国家疗养院居民评估工具。