CHANGING EATING PATTERNS TO MEET LOW FAT GOALS: DISC

改变饮食模式以实现低脂肪目标：DISC

• 批准号: 6080564
• 负责人: LINDA Verner VAN HORN
• 金额: $ 6.02万
• 依托单位: NORTHWESTERN UNIVERSITY AT CHICAGO
• 依托单位国家: 美国
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-04-01 至 2002-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6080564
• 关键词: behavioral /social science research tag; choice; clinical research; computer data analysis; dietary lipid; human data; middle childhood (6-11); nutrient requirement; nutrition related tag; saturated fat; self help

(Adapted from the applicant's abstract) The Dietary Intervention Study in Children (DISC) is an NHLBI-funded clinical trial designed to test the efficacy and safety of a dietary intervention to reduce serum cholesterol levels in 8-10 year-old pre-pubertal children with elevated LDL cholesterol levels. Children were randomized to intervention with a diet that was 28% of energy from total fat, less than 8% from saturated fat, up to 9% from polyunsaturated fat and less than 75mg/4200kJ cholesterol per day or usual care. Three 24-hour recalls were collected by nutritionists trained and certified in the Nutrient Data System of the Nutrition Coordinating Center. Foods were ranked by saturated fat and cholesterol content and classified as GO! and WHOA! foods to help with shopping and making appropriate choices when eating out. Families were educated regarding the types of foods that could be selected to help achieve the study goals, but a variety of individual adaptions occurred. After three years, the intervention group lowered mean dietary intake of total and saturated fat from a mean of 34% at baseline to 28.6%, and serum LDL-C was significantly lower than usual care by 0.09mmol/L (3.3mg/dL, p=.02). These data illustrate adaptation of dietary behavior to achieve the goal nutrient levels, but quantifying the specific changes in eating patterns, food choices and preparation techniques requires further programming and data analyses than what has been already accomplished in this study. Proposed are additional food group analyses to quantify and compare specific food choices adopted within and between groups. By utilizing the GO! vs. WHOA! system, the dietary data collected from over 6,000 recalls will be configured to identify lower vs. higher fat food choices across the overall eating pattern. This will permit better understanding about the self-selected dietary changes that were made in DISC among those children who adhered to the diet, document the level of nutrient adequacy achieved among this cohort and provide potential insights for future translational studies on reduced fat eating in this age group.

（改编自申请人的摘要） 儿童饮食干预研究 (DISC) 是一项由 NHLBI 资助的临床研究 旨在测试饮食干预的有效性和安全性的试验 降低8-10岁青春期前儿童血清胆固醇水平 低密度脂蛋白胆固醇水平升高。 儿童被随机接受干预 饮食中 28% 的能量来自总脂肪，不到 8% 来自饱和脂肪 脂肪，高达 9% 来自多不饱和脂肪，胆固醇含量低于 75mg/4200kJ 每天或常规护理。 营养师收集了 3 次 24 小时召回信息 经过营养学营养数据系统的培训和认证 协调中心。 食物按饱和脂肪和胆固醇排名 内容并分类为 GO！哇哦！有助于购物和制作的食物 外出就餐时适当的选择。 家人接受了相关教育 可以选择有助于实现研究目标的食物类型，但是 发生了各种个体适应。 三年后，干预 小组将总脂肪和饱和脂肪的平均膳食摄入量从 基线时的 34% 降至 28.6%，血清 LDL-C 显着低于平时 护理减少 0.09mmol/L (3.3mg/dL, p=.02)。 这些数据说明了适应 饮食行为以达到目标营养水平，但量化 饮食模式、食物选择和准备技术的具体变化 需要比现有的进一步的编程和数据分析 在这项研究中取得了成就。 建议进行额外的食物组分析 量化并比较组内和组间采用的特定食物选择。 通过使用 GO!与哇！系统，从以上收集的饮食数据 6,000 次召回将被配置为识别低脂肪食品和高脂肪食品的选择 贯穿整体饮食模式。 这将有助于更好地理解 关于 DISC 中自我选择的饮食改变 坚持饮食的儿童记录营养充足的水平 该群体取得的成就，并为未来提供潜在的见解 关于该年龄段减少脂肪饮食的转化研究。