B-Vitamin Intake and Blood Pressure: The INTERMAP Study

B 族维生素摄入量与血压：INTERMAP 研究

• 批准号: 6601290
• 负责人: LINDA Verner VAN HORN
• 金额: $ 12.43万
• 依托单位: NORTHWESTERN UNIVERSITY AT CHICAGO
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-07-01 至 2004-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6601290
• 关键词: American; Chinese; European; Japanese; blood pressure; body composition; clinical research; diet therapy; dietary supplements; disease /disorder prevention /control; epidemiology; folate; high performance liquid chromatography; human data; nuclear magnetic resonance spectroscopy; nutrient intake activity; nutrient requirement; nutrition related tag; questionnaires; riboflavin; thiamine; vitamin B complex; vitamin B6

DESCRIPTION (provided by applicant): INTERMAP is a basic epidemiologic investigation to clarify unanswered questions on the role of macronutrients and micronutrients in the etiology of unfavorable blood pressure (BP) patterns prevailing for most middle-aged and older individuals. Supported by NHLBI, ten primary hypotheses, four subgroup hypotheses and multiple exploratory questions on diet and BP are being addressed in this high-quality international cooperative 17-sample population study of 4,680 men and women ages 40-59 from four countries (China, Japan, UK, US) - of varied ethnic-racial and sociodemographic backgrounds - consuming diverse diets. Analyses use extensive data on nutrient intake from four 24-hour recalls and the 4 country databases (developed by INTERMAP) on nutrient composition of all reported foods (data on 71 nutrients), and from two 24-hr urine collections on Na, K, Ca, Mg, urea, creatinine, volume and microalbuminuria. NHLBI-funded research in progress or pending includes analysis of urinary amino acids of each individual, coding of reported dietary supplements, and special NMR-HPLC analyses of 24-hour urine specimens. New work proposed here - on B vitamin intake and BP - is novel, exploratory, knowledge-generating and "pre-competitive" in nature, in keeping with the aims of this RFA. It is based on new and unprecedented findings, from ongoing INTERMAP analyses for its 2,195 US participants. These data indicate that lower dietary thiamin, riboflavin, B6, and folate (considered singly) is associated with higher systolic BP (SBP), and plays a role in the higher SBP of African-Americans and of less educated Americans of all ethnicities. These results open up a new research area, on B vitamin intake and BP. These analyses were done only for US participants since data on B vitamin composition of foods are missing for Chinese, Japanese, and UK participants. This application requests funds to overcome this data gap, and make possible comprehensive analyses for all 4,680 participants on relations of B vitamin intake (from foods, supplements, and foods plus supplements) to BP, and to other variables, i.e., to make links between data on B vitamin and other nutrient intakes, urinary data on multiple metabolic characteristics (elucidated by routine and special NMR-HPLC analyses), and SBP/DBP - links not available on populations from any other research.

描述（由申请人提供）： Intermap是一项基本的流行病学研究，旨在阐明有关大多数中年和老年人占上风的不利血压（BP）模式病因中大量营养素和微量营养素在病因中的作用的未解决问题。在NHLBI的支持下，十个主要假设，四个亚组假设以及有关饮食和BP的多个探索性问题正在这项高质量的国际合作17样本17样本的人口研究中，对4,680名来自四个国家（中国，英国，美国）的40-680名男女40-59岁的男性和女性 - 关于各种族裔和社会造影背景的饮食 - 消费多样性的饮食量。分析使用四个24小时召回的养分摄入量和4个国家数据库（由Intermap开发）的大量数据在所有报道的食物的养分组成（71个营养素上），以及在Na，K，Ca，Ca，CA，MG，MG，MG，尿素，体积，体积和微蛋白尿中的两个2​​4小时尿液中收集。 NHLBI资助的研究正在进行或待处理中，包括对每个人的尿氨基酸的分析，报告的饮食补充剂的编码以及24小时尿液标本的特殊NMR-HPLC分析。在这里提出的新作品 - 关于B维生素摄入和BP的新作品 - 与此RFA的目标保持一致，是新颖，探索性，知识生成和“预竞争性”。它是基于新的和前所未有的发现，该发现是根据其2,195名美国参与者进行的Intermap分析。这些数据表明，较低的硫胺素，核黄素，B6和叶酸（单独考虑）与较高的收缩BP（SBP）相关，并且在非裔美国人的较高SBP和所有种族的受过较低教育的美国人中都起着作用。这些结果为B维生素摄入和BP开辟了一个新的研究领域。这些分析仅针对美国参与者进行，因为中文，日本和英国参与者缺少有关B维生素成分的数据。该申请要求资金克服这一数据差距，并为所有4,680名参与者提供有关B维生素摄入关系（从食物，补充剂和食物以及补充剂）到BP的全面分析，以及其他变量，即，在B Vitamin和其他营养吸引力的数据上，多种型号的数据（EL）（EL-HOLICALE METAKITS）（EL）（EL-HOLICALITS）（EL）（EL）（EL）在其他变量之间建立联系（即分析）和SBP/DBP-任何其他研究人群都无法获得链接。