Coordinating the remodelling of cell polarity to form a functional organ.

协调细胞极性的重塑以形成功能器官。

基本信息

批准号：
MR/V001256/1
负责人：
Franck Pichaud
金额：
$ 64.28万
依托单位：
University College London
依托单位国家：
英国
项目类别：
Research Grant
财政年份：
2021
资助国家：
英国
起止时间：
2021 至无数据
项目状态：
未结题

来源：
https://gtr.ukri.org/projects?ref=MR%2FV001256%2F1
关键词：
Coordinating remodelling cell polarity form

项目摘要

The cells that make up our tissues adopt complex shapes. In most cases, each cell is able to do part of this process autonomously by defining an intrinsic polarity axis, so they know which end is up and which end is down. For epithelial cells, which line most of our organs, one end must point to the inside and one to the outside. This is true for all organs, and in epithelia is important because it underpins their function in absorbing nutrients (intestine), oxygen (lung) or filtering out salts and toxins (kidney or liver). Loss of polarity affects tissue health and the ability of epithelial cells to adhere to one another, which in turn can lead to cancer cells escaping a tissue to invade another through the process of metastasis. The aim of this programme is to figure out the mechanisms that induce polarised organisation of individual cells, and to determine how these cells work together to form complex multicellular structures in 3D. These structures can consist of cells that arrange themselves into layers found one on top of another, as in the skin or oesophagus, for example. How such tissue organisation is created is not well understood and will be studied with this research grant. Recent work in our laboratory has identified factors that are required for epithelial polarity, some of which have been previously linked to human pathologies. Our results also indicate that mechanical forces might play an essential role in coordinating polarity between cells, as they assemble into a tissue. In summary, we aim to elucidate how cells work together to induce polarised organisation of a complex animal tissue in health and disease.

组成我们组织的细胞采用复杂的形状。在大多数情况下，每个单元都可以通过定义固有的极性轴自动执行此过程的一部分，因此他们知道哪个结尾向上以及哪个结束降低。对于我们大多数器官的上皮细胞，一端必须指向内部，一个指向外部。对于所有器官来说都是如此，并且在上皮中很重要，因为它支持了它们在吸收营养（肠），氧气（肺）或过滤盐和毒素（肾脏或肝脏）的功能。极性的丧失会影响组织健康和上皮细胞彼此粘附的能力，进而导致癌细胞通过转移过程逃脱了组织以侵入另一个。该程序的目的是找出诱导各个细胞极化组织的机制，并确定这些细胞如何共同工作以在3D中形成复杂的多细胞结构。这些结构可以由将自己排列成层的细胞组成，例如在皮肤或食道中，在另一个层上发现了一个细胞。该研究赠款将如何建立这种组织组织的建立方式不充分理解。我们实验室的最新工作确定了上皮极性所需的因素，其中一些以前与人类病理有关。我们的结果还表明，机械力在组装成组织时可能在协调细胞之间的极性方面起着至关重要的作用。总而言之，我们旨在阐明细胞如何共同诱导健康和疾病中复杂动物组织的极化组织。

项目成果

期刊论文数量（8）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

RanBP1 plays an essential role in directed migration of neural crest cells during development

RanBP1 在神经嵴细胞发育过程中的定向迁移中发挥重要作用

DOI：
10.1101/2022.05.05.490747
发表时间：
2022
期刊：
影响因子：
0
作者：
Barriga E
通讯作者：
Barriga E

A combination of Notch signaling, preferential adhesion and endocytosis induces a slow mode of cell intercalation in the Drosophila retina.

DOI：
10.1242/dev.197301
发表时间：
2021-05-15
期刊：
Development (Cambridge, England)
影响因子：
0
作者：
Blackie L;Tozluoglu M;Trylinski M;Walther RF;Schweisguth F;Mao Y;Pichaud F
通讯作者：
Pichaud F

Nanoscale Colocalization of NK Cell Activating and Inhibitory Receptors Controls Signal Integration.

DOI：
10.3389/fimmu.2022.868496
发表时间：
2022
期刊：
Frontiers in immunology
影响因子：
7.3
作者：
通讯作者：

The ultrastructural organization of endoplasmic reticulum-plasma membrane contacts is conserved in epithelial cells.

DOI：
10.1091/mbc.e21-11-0534-t
发表时间：
2022-10-01
期刊：
MOLECULAR BIOLOGY OF THE CELL
影响因子：
3.3
作者：
Chung, Gary Hong Chun;Lorvellec, Maelle;Gissen, Paul;Pichaud, Franck;Burden, Jemima J.;Stefan, Christopher J.
通讯作者：
Stefan, Christopher J.