Epithelial Cell Polarity & Tissue Maintenance

上皮细胞极性

基本信息

批准号：
MC_UU_00012/3
负责人：
Franck Pichaud
金额：
$ 117.86万
依托单位：
University College London
依托单位国家：
英国
项目类别：
Intramural
财政年份：
2017
资助国家：
英国
起止时间：
2017 至无数据
项目状态：
已结题

来源：
https://gtr.ukri.org/projects?ref=MC_UU_00012%2F3
关键词：
Epithelial Cell Polarity Tissue Maintenance

项目摘要

Most of our organs consist of epithelial cells, which are able to adhere to one another to form tissues. Because these cells are so common, it is not surprizing that most cancers come from epithelial tissues, including the intestine, kidney, breast pancreas, lung and skin to name a few. In order to form tissues and stay in place, epithelial cells need to form adhesion domains on their sides so that they can stick to their neighbours. Having formed adhesion domains, these cells can now make their top surface different from their bottom surface. Together with adhesion, the polarization of the epithelial cells is needed for them to work properly. Loss of polarity and adhesion is a hallmark of cancer and pathologists have long relied on assessing epithelial cell shape to diagnose of this disease. Work in our research group focuses on uncovering the mechanisms that regulate polarity and adhesion in epithelial cells. By understanding these mechanisms we will be able to figure out what goes wrong with these cells when cancer arises, and we will be better equipped to prevent or fix the problem.

我们的大多数器官由上皮细胞组成，它们能够相互粘附形成组织。由于这些细胞非常常见，因此大多数癌症来自上皮组织，包括肠、肾、乳腺、胰腺、肺和皮肤等，也就不足为奇了。为了形成组织并保持在原位，上皮细胞需要在其侧面形成粘附域，以便它们能够粘附到邻近的细胞上。形成粘附域后，这些细胞现在可以使其顶面与其底面不同。与粘附一起，上皮细胞的极化是它们正常工作所必需的。极性和粘附力的丧失是癌症的标志，病理学家长期以来依靠评估上皮细胞形状来诊断这种疾病。我们研究小组的工作重点是揭示调节上皮细胞极性和粘附的机制。通过了解这些机制，我们将能够弄清楚当癌症出现时这些细胞出了什么问题，并且我们将能够更好地预防或解决问题。

项目成果

期刊论文数量（8）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Neph/Nephrin-like adhesion and tissue level pulling forces regulate cell intercalation during Drosophila retina development

Neph/Nephrin 样粘附和组织水平拉力调节果蝇视网膜发育过程中的细胞嵌入

DOI：
10.1101/564708
发表时间：
2019
期刊：
影响因子：
0
作者：
Blackie L
通讯作者：
Blackie L

An apical MRCK-driven morphogenetic pathway controls epithelial polarity.

DOI：
10.1038/ncb3592
发表时间：
2017-09
期刊：
Nature cell biology
影响因子：
21.3
作者：
Zihni C;Vlassaks E;Terry S;Carlton J;Leung TKC;Olson M;Pichaud F;Balda MS;Matter K
通讯作者：
Matter K

Rap1, Canoe and Mbt cooperate with Bazooka to promote zonula adherens assembly in the fly photoreceptor.