47--TESLA MRI/MRS CONSOLE UPGRADE

47--特斯拉 MRI/MRS 控制台升级

• 批准号: 2503795
• 负责人: JEFFREY L EVELHOCH
• 金额: $ 27.03万
• 依托单位: WAYNE STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-07-01 至 1999-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2503795
• 关键词: biomedical equipment; biomedical equipment purchase; magnetic resonance imaging; nuclear magnetic resonance spectroscopy

A console upgrade is requested for a 30-cm, 4.7-T MRI/MRS animal research system. Over the ten years since it was installed, only one system component has been upgraded (the gradients were upgraded in fall 1992). The obsolete minicomputer (24-bit, non-UNIX, non-C or -FORTRAN programmable), radiofrequency electronics, and pulse programmer significantly limit its experimental capability and greatly complicate both the development/implementation of new experiments and the on-line analysis of data or transfer of data for off-line analysis. Thus, the current state of the equipment limits both the rate of progress on current projects and the development of future projects. The need to upgrade out current console became critical this past summer when its reliability abruptly degraded to an unacceptable level (it went from an average of 1 day of down time a month over the previous 10 year period to an average of 10 days a month starting in June). This has further decreased the productivity of investigators who depend on this system to conduct their NIH-funded research and discouraged others from beginning new projects. The requested upgrade will make this a reliable, fully functional state-of-the art system. A group of five major users will require at least 90 percent of the total usage of the upgraded system. The projects they will conduct include the following: ascertain the cellular mechanisms regulating the blinding complications associated with diabetic retinopathy of prematurity; elucidate the pathophysiology of pediatric epileptogenesis; evaluate new approaches to predict tumor therapeutic response; monitor cerebral neurochemistry in response to cocaine in vivo; and design optimized data collection and reconstruction strategies for ultimate application to clinical magnetic resonance angiography. All of these animal studies are directly related to ongoing clinical studies in humans and/or parallel basic studies using complimentary methods. Many of the techniques developed on this animal research system will be translated directly to clinical studies. Some of the projects can only be initiated with the upgrade in place, and the remaining projects will benefit enormously form the proposed upgrade.

要求进行30厘米，4.7-T MRI/MRS动物的控制台升级 研究系统。 自安装以来的十年中，只有一个 系统组件已升级（梯度在秋季升级 1992）。 过时的微型计算机（24位，非unix，non-c或-fortran 可编程），射频电子设备和脉冲程序员 显着限制了其实验能力，并且非常复杂 新实验的开发/实施和在线 数据分析或数据传输以进行离线分析。因此， 设备的当前状态限制了进度率 当前的项目和未来项目的发展。 需要 去年夏天，升级当前控制台在其 可靠性突然降低到不可接受的水平（它来自 前10年的平均每月停机时间1天 从6月开始平均每月10天）。 这有进一步 降低了依赖该系统的研究人员的生产率 进行NIH资助的研究，并劝阻其他人 开始新项目。 请求的升级将使这成为 可靠，功能齐全的最先进系统。 一组五个主要用户将至少需要90％ 升级系统的总使用情况。 他们将进行的项目 包括以下内容：确定调节的细胞机制 与糖尿病性视网膜病变有关的盲并发症 早熟;阐明小儿癫痫发生的病理生理； 评估预测肿瘤治疗反应的新方法；监视器 脑神经化学反应可卡因在体内；和设计 最终的优化数据收集和重建策略 应用于临床磁共振血管造影。 所有这些 动物研究与正在进行的临床研究直接相关 人类和/或使用免费方法的基础研究。许多 该动物研究系统中开发的技术将是 直接转化为临床研究。 一些项目只能 通过升级来启动，其余项目将 福利极大地构成了拟议的升级。