DEVELOPMENTAL ADAPTATION

发育适应

• 批准号: 2838753
• 负责人: JOSEPH B WARSHAW
• 金额: $ 35万
• 依托单位: YALE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1990
• 资助国家: 美国
• 起止时间: 1990-09-30 至 2000-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2838753
• 关键词: DNA; Xenopus oocyte; biomedical facility; career; child health care personnel; computer assisted sequence analysis; genetically modified animals; growth /development; in situ hybridization; mammalian embryology; molecular biology; molecular cloning; nucleic acid chemical synthesis; oligonucleotides; pediatrics; physicians; polymerase chain reaction; recombinant proteins

The Child Health Research Center Program at Yale University School of Medicine is designed to provide intensive basic research experience necessary to prepare young pediatric faculty for productive and independent careers in biomedical research and academic pediatrics. The theme of this proposal, Developmental Adaptation, has unique relevance to pediatrics. It encompasses normal developmental biology as well as the adaptation of the fetus and child to insults occurring during onto genesis. The multidisciplinary nature of the program -- drawing from the experience of established scientists in the Department of Pediatrics, Biology, Cell Biology, Immunobiology , Genetics, and Cellular and Molecular Physiology -- has evolved from the common interests, frequent interactions, past training of pediatric scientists, and several areas of ongoing collaborative research of the faculty. The program will continue to provide flexible basic research experience for young pediatric scientists through collegial interaction with Center faculty through start-up funding as provided by the Center's New Project Development Awards and through the Center's Molecular Biology Core Laboratory The selection of new project development awardees will be highly competitive and only those individuals with exceptional credentials or potential will be accepted by the Program Executive Committee. There is a recognition that the quality of the research environment will ultimately define the continued success of the program. Laboratories of the Center faculty in the Department of Pediatrics and in the basic science departments will serve as sites for faculty research development. The Molecular Biology Core Laboratory will emphasize the application of molecular techniques to the problems of developmental biology and pathobiology. The Core Laboratory combined with the laboratory resources of the Center faculty will complement and extend the capabilities of the Center to foster the career development of new investigators. The enrichment programs of the Center including regular research seminars and periodic laboratory workshops will also promote interactions among young investigators and Center faculty. Overall , the Center program is enhanced by centralization of laboratory facilities and faculty, the existing interactions amongst research programs within the institution, the many Core laboratory resources which are readily available to researchers, and a recruitment base of highly qualified applicants already attracted to the excellence of the Yale clinical departments and basic sciences.

耶鲁大学学校儿童健康研究中心计划 医学旨在提供密集的基础研究经验 为年轻的小儿教师准备生产力和 生物医学研究和学术儿科的独立职业。这 该提案的主题，发展适应，与 儿科。 它涵盖了正常的发育生物学以及 适应胎儿和儿童对侮辱的侮辱 创世纪。 程序的多学科性质 - 从 儿科系成熟科学家的经验， 生物学，细胞生物学，免疫生物学，遗传学和细胞以及 分子生理学 - 从共同利益发展，频繁 互动，过去对儿科科学家的培训以及 该教师正在进行的合作研究。 该程序将继续 为年轻的小儿提供灵活的基础研究经验 科学家通过与中心教师的联合互动通过 该中心的新项目开发提供的启动资金 奖项以及通过中心的分子生物学核心实验室 新的项目开发获奖者的选择将是高度的 竞争激烈，只有那些具有特殊证书或 计划执行委员会将接受潜力。 有 认识到研究环境的质量最终将 定义该计划的持续成功。 中心实验室 儿科和基础科学系的教师 部门将作为教师研究发展的地点。 这 分子生物学核心实验室将强调应用 分子技术到发育生物学和 病理生物学。 核心实验室与实验室资源相结合 中心教师将补充并扩展 促进新调查员职业发展的中心。 这 该中心的丰富计划，包括定期研究研讨会和 定期实验室研讨会还将促进年轻人之间的互动 调查人员和中心教师。 总体而言，中心计划是 通过集中化实验室设施和教师的集中化，增强 机构内研究计划之间的现有互动， 许多核心实验室资源很容易获得 研究人员和高素质申请人的招聘基地 吸引了耶鲁大学临床部门的卓越和基本 科学。