SCOR--LUNG BIOLOGY AND DISEASES IN INFANTS AND CHILDREN

SCOR--婴儿和儿童的肺生物学和疾病

• 批准号: 2222969
• 负责人: JOSEPH B WARSHAW
• 金额: $ 115.52万
• 依托单位: YALE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1991
• 资助国家: 美国
• 起止时间: 1991-12-30 至 1996-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2222969
• 关键词: child (0-11); hyperoxia; lung disorder; newborn animals; perinatal; premature infant human

This proposal is directed toward improving our understanding of factors associated with neonatal lung injury and its long term clinical consequences. The component projects will examine the basis of acute lung injury as well as the sequence of injury that result in long term structural and functional alterations of the airway. The Center will include 6 major projects in addition to defined cores for administrative and programmatic needs of the Center. Specific projects are: 1) Neonatal Lung Matrix Drives Lung Repair. This study will define the influence of oxidant injury on lung epithelial basement membrane matrix interactions; 2) Alveolar Epithelial Differentiation in Oxidant Injury. This study will examine the influence of oxidant injury on Na+/K+ ATPase and gammaglutamyltransferase in lung; 3) Relationship Between Stress Proteins and Antioxidants in Hyperoxia. The heat shock response has been shown to be important in a variety of systems involved in injury and repair. We will examine heat shock proteins in relationship to endogenous antioxidant mechanisms following hyperoxic insult; 4) Regulation of Surfactant Phospholipid Metabolism in Injured Adult and Developing Lungs. This project will examine surfactant phospholipid synthesis in different populations of type II cells following silica induced lung injury; 5) The Influence of Butyrate Acid on SP-A Gene Transcription. This project will study the response of lung to a specific biochemical insult associated with alterations in gene expression; 6) Energetics of Breathing in Infants with Chronic Lung Disease. In this project, we will study alterations in lung work, respiratory efficiency and energy expenditure in infants with BPD who represent the final common pathway of acute lung injury. The SCOR will include 2 Cores which will provide support for the programmatic, educational, and oversight components as well as biostatistical support and a shared instrument facility. A shared morphology and electron microscopy core will provide support for the component laboratory projects. The interactions and shared knowledge provided through the Center will lead to a better understanding of the events underlying lung injury that will be essential before rational strategies for prevention can be rigorously developed and tested.

该提议旨在改善我们对因素的理解 与新生儿肺损伤及其长期临床有关 结果。 组件项目将检查急性肺的基础 损伤以及长期导致的伤害序列 气道的结构和功能改变。 中心将 除了确定的核心外，还包括6个主要项目 和中心的编程需求。 特定项目是：1）新生儿 肺部矩阵驱动肺修复。 这项研究将定义 肺上皮地下膜基质相互作用上的氧化剂损伤； 2） 氧化剂损伤中的肺泡上皮分化。 这项研究会 检查氧化剂损伤对Na+/K+ ATPase和 肺中的γ谷氨基转移酶； 3）压力蛋白之间的关系 和高氧中的抗氧化剂。 热冲击响应已显示为 在涉及伤害和修复的各种系统中很重要。 我们 将检查与内源性抗氧化剂关系中的热休克蛋白 高氧损伤后的机制； 4）表面活性剂的调节 受伤的成年和发育肺部受伤的磷脂代谢。 这 项目将检查不同的表面活性剂磷脂合成 二氧化硅后II型细胞的种群诱导肺损伤； 5） 丁酸酸对SP-A基因转录的影响。 这个项目将 研究肺对与 基因表达的改变； 6）婴儿的呼吸能量 慢性肺部病。 在这个项目中，我们将研究肺部的变化 BPD的婴儿的工作，呼吸效率和能量消耗 代表急性肺损伤的最终常见途径。 SCOR会 包括2个核心，这些核心将为程序化提供支持， 教育和监督组成部分以及生物统计学支持以及 共享的仪器设施。 共享的形态和电子显微镜 核心将为组件实验室项目提供支持。 这 通过中心提供的互动和共享知识将导致 更好地了解将是肺部损伤的事件 在预防理性策略之前，必不可少 开发和测试。