DEVELOPMENTAL ADAPTATION

发育适应

• 批准号: 3103053
• 负责人: JOSEPH B WARSHAW
• 金额: $ 30.59万
• 依托单位: YALE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1990
• 资助国家: 美国
• 起止时间: 1990-09-30 至 1995-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3103053
• 关键词: growth /development

The Hallmark of Pediatric science is to recognize and remedy those adverse genetic and environmental influences that can limit the capacity of a child to achieve his/her greatest potential. The goal will require the successfu training of a cadre of pediatrician/scientists who can bring the excitement and technology of modern basic science to improve our understanding of normal developmental events and to those abnormalities of development that continue to result in injury, handicaps and death. The theme of this application, Developmental Adaptation, has unique relevance to Pediatrics. It encompasses normal developmental biology and physiology and the adaptation of the fetus and child to insult occurring during the period of development. The faculty of the program will include a primary faculty in the Department of Pediatrics working closely with an institution-wide resource faculty comprised of pediatrician/scientists, cellular and molecular biologists, neuroscientists, and geneticists who, together with the primary faculty, will guide the young investigators selected for support by this program. The research environment for the four young faculty selected to participate in our Program will be carefully reviewed by the program Advisory Committee with the full recognition that the quality of the environment will ultimately define the success of the program. Laboratories of the Primary and Resource Faculty in the Department of Pediatrics, Yale Center for Molecular Medicine and other departments will serve as the sites for facult research development. The research experience will be enhanced by the educational and programmatic components that will provide an ongoing forum for research interaction of young faculty. We have defined a core laboratory that will support the tissue culture and transgenic mouse needs for a number of investigators whom we have identified as being potential candidates for this program. These specific core facilities combined with the resources of the Primary and Resource Faculty will provide a broad spectrum of scientific investigation to support this program. The Department of Pediatrics provides a large base of training opportunitie including several NIH supported training grants, an NIH funded Children's Clinical Research Center and a highly interactive research oriented faculty A CHRC at Yale will provide an outstanding milieu for interaction, collaboration, and the continued scientific development of young faculty.

小儿科学的标志是识别和纠正那些不利的 遗传和环境影响可以限制儿童的能力 为了发挥最大的潜力。 目标将需要成功 培训可以带来兴奋的儿科医生/科学家的干部 和现代基础科学技术，以提高我们对 正常的发展事件以及那些发展的异常 继续导致受伤，障碍和死亡。 该应用程序的主题是发展适应，具有独特的 与儿科有关。 它包括正常的发育生物学和 生理学以及胎儿和孩子的适应 在发展期间。 该计划的教师将包括 儿科系的主要教职员工与 由儿科医生/科学家组成的机构范围内的资源教师 细胞和分子生物学家，神经科学家和遗传学家，他们 与主要教师一起，将指导年轻的调查员 选择该程序的支持。 四个年轻教师选择参加的研究环境 计划咨询委员会将在我们的计划中仔细审查 充分认识到环境的质量将 最终定义了该程序的成功。 初级实验室 耶鲁大学中心儿科学系的资源学院 分子医学和其他部门将作为教师的地点 研究开发。 研究经验将通过 教育和程序化组件将提供一个正在进行的论坛 用于年轻教师的研究互动。 我们定义了一个核心 将支持组织培养和转基因小鼠需求的实验室 对于许多我们确定为潜在的调查员 该计划的候选人。 这些特定的核心设施与 主要和资源教师的资源将提供广泛的 支持该计划的科学研究范围。 儿科部提供了大量的培训机会基础 NIH资助的儿童还包括几项NIH支持的培训补助金 临床研究中心和高度互动研究的教师 耶鲁大学的CHR将为互动提供出色的环境， 合作以及年轻教师的持续科学发展。