Investigating the renal microvasculature in polycystic kidney disease

研究多囊肾病的肾脏微血管系统

• 批准号: MR/P018629/1
• 负责人: David Long
• 金额: $ 51.59万
• 依托单位: University College London
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2017
• 资助国家: 英国
• 起止时间: 2017 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=MR%2FP018629%2F1
• 关键词: Investigating; renal; microvasculature; polycystic; kidney

60,000 people in the UK have long term severe kidney disease. There is currently no cure and patients require dialysis or transplantation. One of the leading causes of long term kidney disease is polycystic kidneys. Our previous work has shown that one of the earliest events in the progressive decline of polycystic kidneys is changes in the small blood vessels of the kidney. Furthermore, we have shown that treatments using proteins which restore and stabilise these blood vessels improve disease progression. However, we do not yet fully understand how these treatments work. This will be investigated in this proposal by a team of scientists and clinicians based at the UCL Great Ormond Street Institute of Child Health and the University of Manchester using high resolution imaging, high-throughput sequencing technology and models which replicate polycystic kidney disease. These investigations will enhance our knowledge of how blood vessels are involved in kidney health and disease. Furthermore, if these studies are successful, it could be a new exciting therapeutic avenue for kidney patients in the future.

英国有 60,000 人患有长期严重肾脏疾病。目前尚无治愈方法，患者需要透析或移植。长期肾脏疾病的主要原因之一是多囊肾。我们之前的工作表明，多囊肾逐渐衰退的最早事件之一是肾脏小血管的变化。此外，我们已经表明，使用恢复和稳定这些血管的蛋白质进行治疗可以改善疾病进展。然而，我们尚未完全了解这些治疗方法是如何发挥作用的。伦敦大学学院大奥蒙德街儿童健康研究所和曼彻斯特大学的科学家和临床医生团队将在本提案中利用高分辨率成像、高通量测序技术和复制多囊肾病的模型对此进行研究。这些研究将增强我们对血管如何参与肾脏健康和疾病的了解。此外，如果这些研究成功，未来可能会为肾脏患者提供一个令人兴奋的新治疗途径。

项目成果

The timing of auditory sensory deficits in Norrie disease has implications for therapeutic intervention.

诺里病中听觉感觉缺陷的发生时间对于治疗干预具有重要意义。

• DOI: http://dx.10.1172/jci.insight.148586
• 发表时间: 2022
• 期刊: JCI insight
• 影响因子: 8
• 作者: Bryant D

Diabetic Nephropathy - Methods and Protocols

糖尿病肾病 - 方法和方案

• DOI: http://dx.10.1007/978-1-4939-9841-8_8
• 发表时间: 2020
• 作者: Jafree D

SGLT2 Inhibitor, Canagliflozin, Attenuates Myocardial Infarction in the Diabetic and Nondiabetic Heart.

SGLT2 抑制剂 Canagliflozin 可减轻糖尿病和非糖尿病心脏的心肌梗死。

• DOI: http://dx.10.1016/j.jacbts.2018.10.002
• 发表时间: 2019
• 期刊: JACC. Basic to translational science
• 作者: Lim VG

Systemic gene therapy with thymosin ß4 alleviates glomerular injury in mice.

胸腺肽 α4 的全身基因治疗可减轻小鼠的肾小球损伤。

• DOI: http://dx.10.1038/s41598-022-16287-z
• 发表时间: 2022
• 期刊: Scientific reports
• 影响因子: 4.6
• 作者: Mason WJ

Planar cell polarity in organ formation.

器官形成中的平面细胞极性。

• DOI: http://dx.10.1016/j.ceb.2018.06.011
• 发表时间: 2018
• 期刊: Current opinion in cell biology
• 影响因子: 7.5
• 作者: Henderson DJ