MEDICINAL CHEMISTRY

药物化学

基本信息

批准号：
7821297
负责人：
SAEED Rehman KHAN
金额：
$ 17.52万
依托单位：
JOHNS HOPKINS UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
资助国家：
美国
起止时间：
至
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/7821297
关键词：
Antineoplastic Agents Area Arts Basic Science Biochemical Biocompatible Materials Biological Assay Biomedical Research Cancer Center Cancer Center Support Grant Chemicals Chemistry Chromatin Structure Clinical Clinical Drug Development Column Chromatography Communities Contracts Cost Sharing Custom Development Documentation Drug Compounding Equilibrium Equipment Force of Gravity Freeze Drying Frequencies Goals Growth Heating High Pressure Liquid Chromatography Housing In Vitro Intuition Kilogram Laboratories Lead Leadership Ligands Mass Spectrum Analysis Methods Mission Molecular Target NMR Spectroscopy Organic Synthesis Peptides Pharmaceutical Chemistry Pharmaceutical Preparations Pharmacologic Substance Phase Process Prodrugs Production Protocols documentation Quality Control Reaction Reagent Request for Applications Research Research Peer Review Research Personnel Resources Role Services Signal Transduction Solvents Source Staging Structure Temperature Therapeutic Thin Layer Chromatography Time Titrations Toxic effect Tumor Biology Vacuum Validation Vendor Water Work anticancer research cancer cell cancer therapy chemical synthesis cost cost effective design drug development drug discovery evaporation experience feeding in vivo instrument interest mass spectrometer milligram oncology preclinical study programs quality assurance receptor research study response scale up small molecule solid solution square foot

项目摘要

The Medicinal Chemistry Core is a newly proposed CCSG Core. The Medicinal Chemistry Core Laboratory was developed to provide the needed expertise in the area of synthesis of small molecules, modified peptides and bioconjugates for biomedical research by the Cancer Center research community. Creation of this Core was in direct response to a clearly defined need for providing synthesis of chemical reagents needed for preclinical studies (not for clinical drug development). The guiding principle was that the Center was not attempting to establish a GMP chemical production facility, but a chemical synthesis core laboratory to provide reagent grade compounds for use in validation and proof-of-principle target discovery studies. To accomplish this, there are a large number of investigators within the Center who have a need for a Medicinal Chemistry Core to provide unique reagents. These reagents are needed both for the study of the role of specific molecular targets controlling the growth and survival of cancer cells, as well as for the development of related reagents for cancer treatment. From the 2002 inception of the Medicinal Chemistry Core, its mission has been to provide very specific unique reagents to allow proof of principle and general drug discovery studies and accelerate basic sciences studies. The main purpose of the Medicinal Chemistry Core is: (1) To design and synthesize bioactive molecules in the most cost effective manner possible. (2) To optimize methods of purification of bioactive molecules at high yield. (3) To provide NMR, Mass spectrometry, and HPLC analysis for characterization of new anticancer agents. (4) To provide investigators with custom synthesis of anticancer agents in amounts ranging from milligrams to grams. (5) To provide experience and intuition for identification and optimization of lead compounds as well as promising reagents. This application requests support for a resource which continues to fulfill an essential role for peer reviewed research within the SKCCC.

药物化学核心是新提出的CCSG核心。药物化学核心实验室开发的目的是提供小分子，改良肽和合成领域所需的专业知识癌症中心研究界的生物医学研究生物轭。这个核心的创建直接响应明确定义的需要提供临床前所需的化学试剂的合成研究（不是用于临床药物开发）。指导原则是中心没有试图建立GMP化学生产设施，但化学合成核心实验室可提供试剂等级用于验证和原则目标发现研究的化合物。为此，有一个中心内有大量的调查人员需要药物化学核心独特的试剂。这些试剂都需要研究控制特定分子靶标的作用癌细胞的生长和存活以及用于癌症治疗的相关试剂的发展。从2002年的药物化学核心开始，其使命就是提供非常特定的独特试剂以允许原理和一般药物发现研究证明并加速基础科学研究。药物化学核心的主要目的是：（1）在设计和合成生物活性分子中最具成本效益的方式。（2）优化高生物活性分子的方法屈服。（3）提供NMR，质谱和HPLC分析以表征新的抗癌药。（4）为调查人员提供抗癌剂的自定义合成，范围从毫克到克。（5）提供识别和优化铅化合物的经验和直觉以及有希望的试剂。本申请要求支持一个继续履行重要角色的资源同行审查了SKCCC中的研究。