CORE--ANALYTICAL LABORATORY

核心--分析实验室

• 批准号: 6101618
• 负责人: GEORGE WILDING
• 金额: $ 28.96万
• 依托单位: UNIVERSITY OF WISCONSIN-MADISON
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-04-16 至 2000-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6101618
• 关键词: analytical chemistry; analytical method; atomic absorption spectrometry; biomedical equipment resource; biomedical facility; gas chromatography; high performance liquid chromatography; infrared spectrometry; method development; neoplasm /cancer pharmacology; nuclear magnetic resonance spectroscopy; pharmacokinetics; ultraviolet spectrometry

The UWCCC Analytical Instrumentation Laboratory (AIL) provides a resource for bioanalytical chemistry and pharmacology studies to all UWCCC investigators. These services are important to many programs of the UWCCC, including those involved in clinical trials of new drugs and chemopreventative agents; studies of biochemical markers of drug effect and toxicity; and studies of mechanism of drug action and metabolism. In the last decade, pharmacokinetic/pharmacodynamic (PK/PD) studies have become an integral component of early clinical trials. The facility has the capability of setting up and executing a wide variety of assays as they are needed for new studies and can also offer many of the analytic assays of an ongoing basis as drugs move from early Phase I into Phase II and combination trials.

UWCCC分析仪器实验室（AIL）提供了资源 用于所有UWCCC的生物分析化学和药理学研究 调查人员。这些服务对于UWCCC的许多程序很重要， 包括参与新药物临床试验的参与 化学预防剂；药物效应的生化标记的研究 和毒性；以及药物作用和代谢机制的研究。在 在过去的十年中，药代动力学/药效学（PK/PD）的研究具有 成为早期临床试验的组成部分。设施有 设置和执行各种测定的能力 它们是新研究所需的，还可以提供许多分析 随着药物从第一阶段转移到II期，持续的基础测定 和组合试验。