CHOLINESTERASES IN ALZHEIMER'S DISEASE

胆碱酯酶在阿尔茨海默病中的作用

• 批准号: 3768045
• 负责人: MAREK-MARSEL M MESULAM
• 金额: --
• 依托单位: HARVARD MEDICAL SCHOOL
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3768045
• 关键词: Alzheimer's disease; Downs syndrome; acetylcholinesterase; cholinergic receptors; cholinesterase inhibitors; cholinesterases; dementia; electron microscopy; histochemistry /cytochemistry; human tissue; immunocytochemistry; neuritic plaques; neurochemistry; neurofibrillary tangles

The long term objective is to elucidate the biochemical properties of cholinesterases in the plaques and tangles of Alzheimer's disease. Anatomical, pathological, histochemical, biochemical, immunohistochemical and ultrastructural methods will be used to identify the unique properties of plaque and tangle-bound cholinesterases. This is and important objective because recent observations have revealed a selective and universal enhancement of cholinesterase activity in all plaques and tangles. Furthermore, it appears that these cholinesterases are different from the cholinesterases may thus play an important role in the pathogenesis of Alzheimer's disease. As part of this research, cholinesterase inhibitors that are optimally suited to inhibit the type of cholinesterases associated with plaques and tangles will be sought and identified. Cholinesterase inhibitors with this type of activity profile may be more effective than currently available substances for the treatment of Alzheimer's disease.

长期目标是阐明其生化特性 阿尔茨海默病斑块和缠结中的胆碱酯酶。 解剖学、病理学、组织化学、生化、 将使用免疫组织化学和超微结构方法来鉴定 斑块和缠结胆碱酯酶的独特性质。 这 这是一个重要的目标，因为最近的观察表明 选择性和普遍增强所有胆碱酯酶活性 斑块和缠结。 此外，这些胆碱酯酶似乎 与胆碱酯酶不同，因此可能发挥重要作用 在阿尔茨海默病的发病机制中。 作为这项研究的一部分， 最适合抑制该类型的胆碱酯酶抑制剂 将寻找与斑块和缠结相关的胆碱酯酶 并确定。 具有此类活性的胆碱酯酶抑制剂 配置文件可能比目前可用的物质更有效 阿尔茨海默病的治疗。