NONINVASIVE LOCALIZED IN VIVO BLOOD OXIMETRY USING MRI

使用 MRI 进行非侵入性体内血氧饱和度测定

• 批准号: 6030630
• 负责人: ALBERT MACOVSKI
• 金额: $ 27.19万
• 依托单位: STANFORD UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1992
• 资助国家: 美国
• 起止时间: 1992-02-01 至 2001-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6030630
• 关键词: adult human (21+); bioimaging /biomedical imaging; cardiovascular disorder diagnosis; child (0-11); clinical research; congenital heart disorder; heart rate; hemodynamics; human subject; infant human (0-1 year); laboratory rabbit; magnetic resonance imaging; method development; noninvasive diagnosis; oximetry

DESCRIPTION (Adapted from Applicant's Abstract): This re-submission for a competitive renewal aims towards continuing to develop and verify MR oximetry techniques for noninvasive assessment of congenital heart disease. The proposed goal will be approached in three stages. First, they propose to perform an initial clinical study to establish that MR oximetry, with straightforward modifications, can already answer significant clinical questions for cooperative patients who have heart defects with stable hemodynamics, typically atrial septal defects. The second stage will address the problem of performing MR measurements in cooperative patients with adverse flow characteristics such as high flow jets. The third stage extends the application of the previously developed techniques to infants and children where the anatomy is smaller, heart rates are faster, and the ability to cooperate is reduced. At each stage, technically more challenging advances in the measurement process will be required and developed progressively. The results of this investigation will significantly enhance the management of children and young adults with congenital heart disease while extending the general utility of MR oximetry.

描述（改编自申请人的摘要）：此重新提交 竞争性更新旨在继续发展和验证MR 对先天性心脏病无创评估的血氧仪技术。 提议的目标将在三个阶段实现。 首先，他们建议 进行最初的临床研究以确定先生的血氧饱和度，并具有 直接修改，已经可以回答重要的临床 对于患有稳定心脏缺陷的合作患者的问题 血液动力学，通常是心房间隔缺陷。 第二阶段将 解决合作患者进行MR测量的问题 具有不良流动特性，例如高流动喷气机。 第三阶段 扩展了先前开发的技术对婴儿的应用 和解剖学较小的儿童，心率更快，并且 合作的能力降低了。 在每个阶段，从技术上讲更多 需要在测量过程中挑战性进步，并且 逐渐发展。 这项调查的结果将 显着增强了儿童和年轻人的管理 先天性心脏病，同时扩大了先生的血氧饱和度的一般效用。

项目成果

A comprehensive approach using MR imaging to diagnose acute segmental mesenteric ischemia in a porcine model.

使用 MR 成像诊断猪模型急性节段性肠系膜缺血的综合方法。

• DOI: 10.2214/ajr.173.3.10470873
• 发表时间: 1999
• 期刊: AJR. American journal of roentgenology
• 作者: Chan,FP;Li,KC;Heiss,SG;Razavi,MK
• 通讯作者: Razavi,MK

In vivo flow-independent T2 measurements of superior mesenteric vein blood in diagnosis of chronic mesenteric ischemia: a preliminary evaluation.

肠系膜上静脉血的体内流动独立 T2 测量诊断慢性肠系膜缺血：初步评估。

• DOI: 10.1016/s1076-6332(99)80430-9
• 发表时间: 1999
• 期刊: Academic radiology.
• 作者: Li,KC;Dalman,RL;Wright,GA
• 通讯作者: Wright,GA

Magnetic resonance angiography of the visceral arteries: techniques and current applications.

内脏动脉磁共振血管造影：技术和当前应用。

• DOI: 10.1055/s-2007-1004254
• 发表时间: 1997
• 期刊: Endoscopy.
• 作者: Li,KC

Oxygen saturation of blood in the superior mesenteric vein: in vivo verification of MR imaging measurements in a canine model. Work in progress.

肠系膜上静脉血氧饱和度：犬模型中 MR 成像测量的体内验证。

• DOI: 10.1148/radiology.194.2.7824705
• 发表时间: 1995
• 期刊: Radiology.
• 作者: Li,KC;Wright,GA;Pelc,LR;Dalman,RL;Brittain,JH;Wegmueller,H;Lin,DT;Song,CK
• 通讯作者: Song,CK

Validation of in vivo MR measurement of oxygen saturation after resuscitation with a hemoglobin-based oxygen carrier in a rabbit model.

在兔模型中使用基于血红蛋白的氧载体复苏后体内 MR 测量血氧饱和度的验证。

• DOI: 10.1016/s1076-6332(03)80682-7
• 发表时间: 2001
• 期刊: Academic radiology
• 影响因子: 4.8
• 作者: Chan,FP;Jahr,JS;Driessen,B;Daunt,DA;Li,KC
• 通讯作者: Li,KC