UK-India Centre for Advanced Technology for Minimising the indiscriminate use of

英国-印度先进技术中心尽量减少滥用

基本信息

批准号：
MR/N501888/1
负责人：
Stephen Rimmer
金额：
$ 115.43万
依托单位：
University of Sheffield
依托单位国家：
英国
项目类别：
Research Grant
财政年份：
2015
资助国家：
英国
起止时间：
2015 至无数据
项目状态：
已结题

来源：
https://gtr.ukri.org/projects?ref=MR%2FN501888%2F1
关键词：
UK India Centre Advanced Technology

项目摘要

Resistance to antibiotics is becoming one of the most important challenges of our age. A number of challenges exist if we are to avoid decent into a post-antibiotic age, including development of: new antibiotics; new diagnostics and improved delivery systems. The UK-India Centre for Advanced Technology for Minimising the indiscriminate use of Antibiotics (UKICAT-MA) will establish materials for both detection, at the point-of-care, of ocular infections and the targeted delivery of antibiotics to infected sites in the eye. UKICAT-MA will also promote the use of these technologies in other infective diseases. The Centre involves a multidisciplinary team from the University of Sheffield (Polymer Chemistry, Clinical and Mechanistic Microbiology and LV Prasad Ophthalmology). Much of the work is based around the idea that certain materials respond to bacteria by changing state on binding to bacteria. These conformational changes are then either monitored to provide a signal of the presence of the bacteria or they provide a basis for targeting antibiotics to bacteria whilst reducing effects on surrounding tissues. UKICAT-MA will develop these smart materials to produce contact lenses that give colourimetric indications of bacterial infections and systems for local delivery of therapeutics to infected ocular tissues. The Centre involves basic science activities, which are aimed at understanding the binding interactions that are key aspects of these materials, materials development and development of manufacturing strategies through to clinical trials. Close collaborative working between the UK and India will facilitate this ambitious programme and each partner brings important expertise to progress these technologies efficiently and quickly to the clinic. UKICAT-MA will also look to collaborate with new partners: industrial, clinical and scientific with expertise of infections other than in eyes. To facilitate these further researches we will run a series of workshops in both India and the UK.

对抗生素的抵抗正在成为我们这个时代最重要的挑战之一。如果我们要避免在抗生物后的年龄中体面，包括：新抗生素；新的诊断和改进的交付系统。英国 - 印度高级技术中心，用于最大程度地减少抗生素的不加区分使用（UKICAT-MA），将建立材料，以供检测，即医疗点，眼部感染和靶向抗生素靶向输送到感染的部位。 Uqicat-MA还将促进这些技术在其他感染疾病中的使用。该中心涉及谢菲尔德大学的多学科团队（聚合物化学，临床和机械微生物学以及LV Prasad Ophthalmology）。大部分工作都是基于这样的想法，即某些材料通过改变与细菌结合的状态来反应细菌。然后，对这些构象变化进行监测以提供细菌存在的信号，或者为将抗生素靶向细菌提供基础，同时减少对周围组织的影响。 Uqicat-MA将开发这些智能材料，以产生隐形眼镜，从而为细菌感染和系统提供涂色的指示，以局部送给感染眼组织的治疗疗法。该中心涉及基础科学活动，旨在理解这些材料的关键方面，材料开发和制造策略的开发，直到临床试验。英国和印度之间的密切合作工作将促进这一雄心勃勃的计划，每个合作伙伴都将重要的专业知识有效，迅速地发展到诊所。 Uqicat-MA还将与新的合作伙伴合作：工业，临床和科学，并具有眼睛以外的其他感染专业知识。为了促进这些进一步的研究，我们将在印度和英国举办一系列研讨会。