REAL-TIME ULTRASONIC TISSUE IMAGING FOR PROSTATE CANCER

前列腺癌的实时超声组织成像

• 批准号: 6015558
• 负责人: RICHARD Bruce BERNARDI
• 金额: $ 53.13万
• 依托单位: SPECTRASONICS, INC.
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-09-01 至 2001-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6015558
• 关键词: bioimaging /biomedical imaging; biomedical equipment development; biopsy; computer assisted patient care; diagnosis design /evaluation; human subject; male; neoplasm /cancer diagnosis; prostate neoplasms

Spectrasonics Imaging, Inc. proposes a Phase II effort in collaboration with Riverside Research Institute (RRI) to develop a real-time ultrasonic, imaging system for indicating regions of the prostate that are suspicious for cancer. Real-time images produced by the system will enable better guidance of needle biopsies. Current ultrasonic guidance of biopsies has an unsatisfactory sensitivity and specificity for prostate cancer. As a consequence, the great majority of prostate biopsies are negative, resulting in an unacceptably high false negative rate. Studies by RRI suggest that the Spectral-Parameter Imaging (SPI) methods underlying the proposed system can improve detection of prostate cancer by 50 percent, which could detect 150,000 additional cancers annually in the US, reduce the need for repeat biopsies, and permit earlier initiation of treatment. The proposed SBIR study seeks to develop a real-time imaging system that uses color encoding to depict suspicious regions of the prostate. This color-encoding will be based on spectrum analysis of ultrasonic rf echo signals. We anticipate that biopsy efficacy can be markedly improved through increases in the sensitivity and specificity of such biopsy-guidance images. PROPOSED COMMERCIAL APPLICATION Over 1,000,000 prostate biopsies occur annually in the U.S. alone. Approximately 70 percent are negative, and over half of the negative biopsies are false. Repeat biopsies have almost the same incidence of positive biopsies as the initail exam. Unnecessary repeat biopsies and missed cancers impose an enromous dollar cost and patient risk. The proposed SPI methods appear capable of improving cancer detection by 50 percent which should prove clinically significant and commercially valuable.

Spectrasonics Imaging, Inc. 提议与 Riverside Research Institute (RRI) 合作开展第二阶段工作，开发实时超声波成像系统，用于指示前列腺中可疑癌症的区域。 该系统产生的实时图像将能够更好地指导针刺活检。 目前超声引导活检对前列腺癌的敏感性和特异性均不令人满意。因此，绝大多数前列腺活检呈阴性，导致假阴性率高得令人无法接受。 RRI 的研究表明，该系统所采用的光谱参数成像 (SPI) 方法可以将前列腺癌的检测率提高 50%，这可以在美国每年检测出 150,000 例额外的癌症，减少重复活检的需要，并允许更早开始的治疗。 拟议的 SBIR 研究旨在开发一种实时成像系统，使用颜色编码来描绘前列腺的可疑区域。 这种颜色编码将基于超声波射频回波信号的频谱分析。 我们预计，通过提高此类活检引导图像的敏感性和特异性，可以显着提高活检效果。拟议的商业应用 仅在美国每年就会进行超过 1,000,000 例前列腺活检。 大约 70% 的活检呈阴性，超过一半的阴性活检是假的。 重复活检的阳性活检发生率几乎与初始检查相同。不必要的重复活检和遗漏的癌症会带来巨大的成本和患者风险。 所提出的 SPI 方法似乎能够将癌症检测提高 50%，这应该具有临床意义和商业价值。