ULTRASONIC EPICARDIAL ABLATION FOR TREATING ATRIAL FIB.

超声心外膜消融术治疗心房颤动。

• 批准号: 6642976
• 负责人: RICHARD Bruce BERNARDI
• 金额: $ 8.76万
• 依托单位: SPECTRASONICS, INC.
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-04-08 至 2003-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6642976
• 关键词: atrial fibrillation; bioengineering /biomedical engineering; biomedical equipment development; cardiovascular disorder therapy; heart conduction system; mathematical model; ultrasonography; ultrasound therapy

DESCRIPTION (provided by applicant): Spectrasonics Imaging, in collaboration with Riverside Research Institute (RRI) and Columbia Presbyterian Hospital proposes a Phase I effort to design, acquire and evaluate a linear array high intensity focused ultrasound (HIFU) transducer for the application of epicardial ablation for treating atrial fibrillation (AF). The transducer is to have both HIFU and pulse echo imaging capability - the latter for monitoring tissue change during the ablation and thereby controlling the process. HIFU has advantages over other ablation energy sources (e.g. RF) because the energy can be focused to produce homogeneous transmural lesions. The long term objective is to develop a system that will safely and effectively ablate the left atrium in a pattern that will block conduction from aberrant foci causing AF. The initial patient population will be AF patients undergoing cardiac surgery such as coronary artery bypass grafts (CABG) and mitral valve replacement (MVR). Eventually it may be possible to conduct the procedure thoroscopically and treat a much wider AF population. The Phase 1 program will involve determining frequency, size, focal and intensity requirements, devising a practical transducer design, and then modeling the design to verify beam shape and the resulting tissue temperature and damage.

描述（由申请人提供）： Spectrasonics Imaging 与河滨研究所 (RRI) 和哥伦比亚长老会医院合作，提出了一项第一阶段工作，旨在设计、获取和评估线性阵列高强度聚焦超声 (HIFU) 换能器，用于心外膜消融治疗心房颤动 (AF) ）。该换能器具有 HIFU 和脉冲回波成像功能 - 后者用于监测消融过程中的组织变化，从而控制该过程。 HIFU 比其他消融能源（例如射频）具有优势，因为能量可以集中产生均匀的透壁病变。长期目标是开发一种系统，能够安全有效地消融左心房，并阻断引起房颤的异常病灶的传导。最初的患者群体将是接受冠状动脉旁路移植术（CABG）和二尖瓣置换术（MVR）等心脏手术的房颤患者。最终，有可能通过胸腔镜进行手术并治疗更广泛的房颤人群。第一阶段计划将涉及确定频率、尺寸、焦点和强度要求，设计实用的换能器设计，然后对设计进行建模以验证光束形状以及由此产生的组织温度和损伤。