Ablation Fiber Optic Probe for Surgical Maze Procedure

用于迷宫手术的消融光纤探头

• 批准号: 6883780
• 负责人: VLADIMIR RUBTSOV
• 金额: $ 13.31万
• 依托单位: INTELLIGENT OPTICAL SYSTEMS, INC.
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-02-01 至 2005-10-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6883780
• 关键词: atrial fibrillation; bioengineering /biomedical engineering; biomedical equipment development; cardiovascular surgery; fiber optics; heart catheterization; photocoagulation therapy; surgery material /equipment

DESCRIPTION (provided by applicant): Atrial fibrillation (AF) is a heart rhythm abnormality that involves irregular, and often rapid heartbeats. Billions of dollars are spent annually to diagnosis and treat this disorder. Recent studies demonstrate the feasibility of treating AF and other structural heart diseases with limited, left-atrial ablation lesion sets, using alternative energy sources These cardiac ablation procedures reduce the time required to perform the maze procedure surgery, and are less invasive. Radiofrequency (RF) remains the energy delivery system of choice, but it has several serious limitations, including the need for good electrode-tissue contact. This is difficult, and may lead to superficial lesions. Continuous wave lasers and laser diodes have been used experimentally, and while these laser treatments were superior, they required catheters that do not exist today, for producing long continuous transmural lesions. Intelligent Optical Systems (IOS) in conjunction with its collaborators, Dr. Hillel Laks of the UCLA Medical Center and Photonics Research Ontario, proposes to develop a unique fiber optic laser energy delivery catheter for the treatment of atrial fibrillation. This new instrument will provide physicians with a tool for producing viable lesions with minimum damage to the surrounding tissue. The proposed system will be a vast improvement over existing tools and will be valuable for the treatment of AF. Phase I research will focus on developing and testing a side emitting fiber optic diffuser at least 10cm long, fabricating and testing all critical elements of the catheter, and outlining the design of the working prototype. In Phase II, a working prototype of the catheter will be developed and tested in the laboratory, and in animal studies, at the UCLA Medical Center.

描述（由申请人提供）： 心房颤动 (AF) 是一种心律异常，表现为心跳不规则且通常较快。 每年花费数十亿美元来诊断和治疗这种疾病。最近的研究证明了使用替代能源通过有限的左心房消融病变组治疗房颤和其他结构性心脏病的可行性。这些心脏消融手术减少了进行迷宫手术所需的时间，并且侵入性较小。射频 (RF) 仍然是首选的能量输送系统，但它有一些严重的局限性，包括需要良好的电极与组织接触。这很困难，并且可能导致浅表病变。连续波激光器和激光二极管已在实验中使用，虽然这些激光治疗效果优越，但它们需要当今不存在的导管来产生长的连续透壁损伤。智能光学系统 (IOS) 与其合作者加州大学洛杉矶分校医学中心和安大略省光子学研究中心的 Hillel Laks 博士合作，提议开发一种独特的光纤激光能量输送导管，用于治疗心房颤动。这种新仪器将为医生提供一种工具，可以在对周围组织造成最小损害的情况下产生可行的损伤。 所提出的系统将是对现有工具的巨大改进，并且对于 AF 的治疗很有价值。第一阶段研究将重点开发和测试至少 10 厘米长的侧面发射光纤扩散器，制造和测试导管的所有关键元件，并概述工作原型的设计。在第二阶段，导管的工作原型将在加州大学洛杉矶分校医学中心的实验室和动物研究中开发和测试。