Ablation Fiber Optic Probe for Surgical Maze Procedure

用于迷宫手术的消融光纤探头

• 批准号: 6883780
• 负责人: VLADIMIR RUBTSOV
• 金额: $ 13.31万
• 依托单位: INTELLIGENT OPTICAL SYSTEMS, INC.
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-02-01 至 2005-10-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6883780
• 关键词: atrial fibrillation; bioengineering /biomedical engineering; biomedical equipment development; cardiovascular surgery; fiber optics; heart catheterization; photocoagulation therapy; surgery material /equipment

DESCRIPTION (provided by applicant): Atrial fibrillation (AF) is a heart rhythm abnormality that involves irregular, and often rapid heartbeats. Billions of dollars are spent annually to diagnosis and treat this disorder. Recent studies demonstrate the feasibility of treating AF and other structural heart diseases with limited, left-atrial ablation lesion sets, using alternative energy sources These cardiac ablation procedures reduce the time required to perform the maze procedure surgery, and are less invasive. Radiofrequency (RF) remains the energy delivery system of choice, but it has several serious limitations, including the need for good electrode-tissue contact. This is difficult, and may lead to superficial lesions. Continuous wave lasers and laser diodes have been used experimentally, and while these laser treatments were superior, they required catheters that do not exist today, for producing long continuous transmural lesions. Intelligent Optical Systems (IOS) in conjunction with its collaborators, Dr. Hillel Laks of the UCLA Medical Center and Photonics Research Ontario, proposes to develop a unique fiber optic laser energy delivery catheter for the treatment of atrial fibrillation. This new instrument will provide physicians with a tool for producing viable lesions with minimum damage to the surrounding tissue. The proposed system will be a vast improvement over existing tools and will be valuable for the treatment of AF. Phase I research will focus on developing and testing a side emitting fiber optic diffuser at least 10cm long, fabricating and testing all critical elements of the catheter, and outlining the design of the working prototype. In Phase II, a working prototype of the catheter will be developed and tested in the laboratory, and in animal studies, at the UCLA Medical Center.

描述（由申请人提供）： 心房颤动（AF）是心律异常，涉及不规则且通常是快速心跳。 每年花费数十亿美元用于诊断和治疗这种疾病。最近的研究表明，使用替代能源来治疗有限的，左右的消融病变组的AF和其他结构性心脏病的可行性，这些心脏消融程序减少了进行迷宫手术所需的时间，并且侵入性较小。射频（RF）仍然是首选的能量输送系统，但它具有严重的局限性，包括需要良好的电极组织接触。这很困难，可能导致肤浅的病变。连续的波激光器和激光二极管已通过实验使用，尽管这些激光治疗较高，但它们需要今天不存在的导管，以产生长时间的连续透壁病变。智能光学系统（IOS）与其合作者，UCLA医疗中心的Hillel Laks博士和Photonics Research Ondario，建议开发一个独特的光纤激光递送导管，以治疗房颤。该新仪器将为医生提供一种工具，用于产生对周围组织损害最小损害的可行病变。 拟议的系统将对现有工具进行巨大改进，对于AF的治疗非常有价值。第一阶段的研究将着重于开发和测试侧发射光纤扩散器至少长10厘米，制造和测试导管的所有关键元素，并概述了工作原型的设计。在第二阶段，将在实验室和动物研究中开发和测试导管的工作原型，并在UCLA医疗中心进行。