BONE LOSS IN THE ORAL CAVITY AND ITS RELATION TO SKELETAL BONE HEALTH

口腔骨质流失及其与骨骼健康的关系

• 批准号: 5201836
• 负责人: M REDFORD
• 金额: --
• 依托单位: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/5201836
• 关键词: aging; clinical trials; dental disorder diagnosis; dental implants; dental radiography; female; human data; menopause; oral health; osteopenia; osteoporosis; pathologic bone resorption; preventive dentistry; tooth loss; women's health

Bone loss in the oral cavity is a significant problem in the United States. In the dentate, oral bone loss may manifest as a loss of tooth support. In edentate individuals, osteopenia may augment local anatomic, biological, and mechanical factors resulting in extensive ridge atrophy. There have been speculations in the medical and dental literature that generalized skeletal osteopenia may be conducive to accelerated loss of oral bone. Thus, skeletal osteopenia may influence the need for and outcome of periodontal, pre-prosthetic, and implant surgical procedures. The objective of this research is to describe changes in oral bone mass and quality with age and in relation to skeletal bone status in health and disease. In accord with the research objectives, investigators from a designated Bone Density Center must recruit 1000 peri- and post-menopausal women enrolled in the observational component of the Women's Health Initiative (WHI). At baseline and at 3 year intervals as dictated by the WHI study protocol, participants will receive a thorough oral examination, including standardized radiographs of the posterior teeth or corresponding edentulous spaces. Interim information on self care will be obtained by querying participants and their dental providers will be asked to provide yearly updates of patient records. Data from the oral component will be linked to the WHI participant's file thereby establishing the framework for descriptive and analytic analyses of tooth and oral bone status in relation to health behaviors, medical status, and skeletal bone density assessments. There is a dearth of information describing changes in oral bone mass and quality with age, and in relation to skeletal bone status in health and disease. Knowledge of an osteoporotic influence on oral bone may be of particular relevance to women with regards to the need for, and outcome of periodontal, preprosthetic and implant surgical procedures.

口腔骨质流失是美国的一个严重问题 国家。 在齿状牙齿中，口腔骨质流失可能表现为牙齿脱落 支持。 在缺齿个体中，骨质减少可能会增强局部解剖学、 生物和机械因素导致广泛的牙槽嵴萎缩。 医学和牙科文献中曾有这样的猜测： 全身性骨骼骨质减少可能有利于加速骨质流失 口腔骨。 因此，骨骼骨质减少可能会影响对骨骼的需求和 牙周、修复前和种植手术过程的结果。 本研究的目的是描述口腔骨量的变化 和质量随年龄的变化以及与健康和骨骼状态的关系 疾病。 根据研究目标，研究人员来自 指定骨密度中心必须招募 1000 名围绝经期和绝经后妇女 参加妇女健康观察部分的妇女 倡议（WHI）。 按照基线和 3 年间隔 WHI 研究方案，参与者将接受彻底的口试， 包括后牙或相应的标准化放射线照片 无牙颌空间。 有关自我护理的临时信息将通过以下方式获得： 询问参与者及其牙科服务提供者将被要求提供 每年更新患者记录。 口头部分的数据将链接到 WHI 参与者的文件 从而建立描述性和分析性分析的框架 牙齿和口腔骨骼状况与健康行为、医疗 状态和骨骼骨密度评估。 缺乏描述口腔骨量变化的信息 质量随年龄的变化，以及与健康和骨骼状态的关系 疾病。了解骨质疏松症对口腔骨的影响可能具有重要意义 在以下方面与妇女特别相关： 牙周、修复前和种植手术。