BONE LOSS IN THE ORAL CAVITY AND ITS RELATION TO SKELETAL BONE HEALTH

口腔骨质流失及其与骨骼健康的关系

• 批准号: 3753605
• 负责人: M REDFORD
• 金额: --
• 依托单位: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3753605
• 关键词: aging; dental implants; human data; menopause; oral health; osteopenia; osteoporosis; pathologic bone resorption

Bone loss in the oral cavity is a significant problem in the United States. In the dentate, oral bone loss may manifest as a loss of tooth support. In edentate individuals, osteopenia may augment local anatomic, biological, and mechanical factors resulting in extensive ridge atrophy. There have been speculations in the medical and dental literature that generalized skeletal osteopenia may be conducive to accelerated loss of oral bone. Thus, skeletal osteopenia may influence the need for and outcome of periodontal, pre-prosthetic, and implant surgical procedures. Conversely, there is evidence that oral assessment may provide a measure of skeletal bone health and, thus, have predictive, diagnostic, or therapeutic value for osteoporosis. This research program represents a series of projects undertaken as follow-up to an NIDR and NIAMS sponsored workshop on osteoporosis and oral bone loss in August, 1992. A special supplement to the Journal of Bone and Mineral Research spotlighting the workshop is being finalized which will ensure the accurate and timely science transfer of the presentations and research recommendations to the extramural community. Another key activity in this area of research focuses on analyses of data derived from collaboration with scientists at Bowman Gray School of Medicine. Now that the computation of fractal-based indices of trabecular bone patterns from existing dental radiographs is complete, analyses will be conducted to assess if these measures correlate with race, age, menopausal status, and medically diagnosed osteoporosis.

口腔骨质流失是一个严重的问题 美国。 在齿状骨中，口腔骨质流失可能表现为损失 的牙齿支撑。 在缺齿个体中，骨质减少可能会增加 局部解剖学、生物和机械因素导致 广泛的脊萎缩。 医学界一直有猜测 和牙科文献表明全身性骨骼骨质减少可能是 有利于口腔骨质加速流失。 因此，骨骼骨质减少 可能会影响牙周、预修复、 和植入手术程序。 相反，有证据表明 口腔评估可以提供骨骼健康的衡量标准， 因此，具有预测、诊断或治疗价值 骨质疏松症。 本研究计划 代表了作为 NIDR 后续行动而开展的一系列项目，并且 NIAMS 于 8 月主办了骨质疏松症和口腔骨质流失研讨会， 1992.《Journal of Bone and Mineral Research》特刊增刊 聚焦研讨会正在最后确定，这将确保 准确、及时地科学转移演示和研究 向校外社区提出建议。 另一项关键活动是 该研究领域的重点是对来自以下来源的数据进行分析 与鲍曼格雷医学院的科学家合作。 现在 基于分形的骨小梁指数的计算 现有牙科射线照片的模式已完成，分析将 进行评估这些措施是否与种族、年龄、 更年期状况和医学诊断的骨质疏松症。