PHYSICOCHEMICAL STUDIES ON CALCIUM PHOSPHATE CEMENTS

磷酸钙水泥的物理化学研究

• 批准号: 5201812
• 负责人: E D EANES
• 金额: --
• 依托单位: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/5201812
• 关键词: apatites; biomaterial compatibility; biomaterial evaluation; calcium phosphate; chemical property; crystallization; dental bonding material; dental implants; mechanical stress; physical chemical interaction; physical property; tensile strength; water solution

Self-setting calcium phosphate cements (CPC) are promising materials which have a variety of possible medical and dental applications. In situ setting and biocompatibility properties make CPCs potentially useful as endodontic filling materials, as implants for bony defects, and as a binder for other implant materials. CPCs are formed by moistening biphasic mixtures of calcium phosphate salts, usually anhydrous dicalcium phosphate (DCPA) and tetracalcium phosphate (TTCP), with limited amounts of water. Although relatively simple materials in composition, other chemical as well as physical properties, e.g. setting times, porosity and strength, are dependent in a complex manner upon a number of poorly understood parameters associated with the chemistry of the setting process. Particularly relevant are the solution parameters important in establishing the crystalline texture (i.e., size, shape, and aggregation properties) of the apatitic product formed upon completion of the DCPA/TTCP conversion, since the texture of this phase is a major determinant of the mechanical behavior of these cements. Thus, studies of solution influences on apatite crystal growth may prove useful in formulating cements with improved mechanical properties.

自设置磷酸钙水泥（CPC）是有前途的材料 有各种可能的医疗和牙科应用。 原位 设置和生物相容性特性使CPC可能有用，因为 牙髓填充材料，作为骨缺陷的植入物，作为 其他植入物材料的粘合剂。 CPC是通过湿润形成的 磷酸钙盐的双相混合物，通常是无水脱皮的 磷酸盐（DCPA）和四钙磷酸盐（TTCP），量有限 水。 虽然构图中的材料相对简单，但其他 化学和物理特性，例如设定时间，孔隙率和 强度，以复杂的方式取决于许多差 了解与设置化学相关的参数 过程。 特别相关的解决方案参数在 建立结晶纹理（即大小，形状和聚集 完成后形成的Apatitic产品的属性） DCPA/TTCP转换，因为此阶段的纹理是主要的 这些水泥的机械​​行为的决定因素。 因此，研究 溶液对磷灰石晶体生长的影响可能对 具有改善机械性能的水泥制定水泥。