AMORPHOUS CALCIUM PHOSPHATE AS AN INORGANIC COMPONENT IN DENTAL MATERIALS

无定形磷酸钙作为牙科材料中的无机成分

• 批准号: 3775741
• 负责人: E D EANES
• 金额: --
• 依托单位: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3775741
• 关键词: amorphous solid; apatites; biomaterial evaluation; calcium; calcium phosphate; chemistry; composite resins; dental adhesive /sealant; dental caries inhibitor; dental casting material; dental materials; normal ossification; periodontium; phosphates; polymethacrylate; slow release drug; tooth surface; topical fluoride therapy

In this project, amorphous calcium phosphate (ACP), an important intermediate in the formation of apatite, is being investigated for possible use as a dental material. When either used alone, or in combination with other dental materials, especially polymeric resins, ACP has a wide range of possible applications such as in restorative composites, cavity liners and bases, luting and pulp capping agents, prophylactic and endodontic sealants, and as a component in periodontic packs and impression pastes. It has a number of potential advantages over other calcium phosphates for these purposes. As a dental cement, its advantage over current biphasic systems (e.g., dicalcium/tetracalcium phosphate mixtures) is its simpler, single solid phase formulation. When included as a component in appropriate resin-based composites, sealants and adhesives, ACP may be useful as a remineralization agent as well as a vehicle for sustained, controlled release of inorganic anticaries ions such as fluoride. Currently, chemical studies on various ACP-resin formulations are being carried out to examine ACP's potential as a remineralization agent. Results to date indicate that discs of ACP- embedded, methacrylate resins release calcium and phosphate ions at levels that exceed the thermodynamic minimum necessary for remineralizing damaged tooth surfaces.

在这个项目中，无定形磷酸钙（ACP），这是一个重要的 正在研究磷灰石形成的中间体 可能用作牙科材料。 当单独使用或在 与其他牙科材料，尤其是聚合物树脂的结合，ACP 具有广泛的可能应用，例如恢复性 复合材料，腔衬里和碱，Luting和纸浆封盖剂， 预防性和牙髓密封剂，并作为牙周成分 包装和印象糊状。 它具有许多潜在的优势 出于这些目的，其他磷酸钙。 作为牙科水泥， 它比当前双相系统的优势（例如，dicalcium/tetracalcium 磷酸盐混合物）是其更简单的单相配方。 什么时候 包括在适当的基于树脂的复合材料中作为组件，密封剂 和粘合剂，ACP可以作为回忆剂以及 一种用于持续，受控释放无机抗性抗性离子的车辆 例如氟化物。 目前，对各种ACP矿化的化学研究 正在执行配方以检查ACP的潜力 回忆剂。 迄今为止的结果表明ACP的光盘 嵌入甲基丙烯酸酯树脂释放钙和磷酸盐离子 超过热力学最低的水平 牙齿表面受损。