AMORPHOUS CALCIUM PHOSPHATE AS AN INORGANIC COMPONENT IN DENTAL MATERIALS

无定形磷酸钙作为牙科材料中的无机成分

• 批准号: 2572362
• 负责人: E D EANES
• 金额: --
• 依托单位: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/2572362
• 关键词: amorphous solid; animal tissue; apatites; biomaterial evaluation; calcium phosphate; composite resins; dental adhesive /sealant; dental caries inhibitor; dental casting material; dental materials; normal ossification; oral facial restoration material; polymethacrylate; tooth filling

In this project, amorphous calcium phosphate (ACP), an important intermediate in the formation of apatite, is being investigated for possible use as a dental material. When either used alone, or in combination with other dental materials, especially polymeric resins, ACP has a wide range of possible applications such as in restorative composites, cavity liners and bases, luting and pulp capping agents, prophylactic and endodontic sealants, and as a component in periodontic packs and impression pastes. It has a number of potential advantages over other calcium phosphates for these purposes. As a dental cement, its advantage over current biphasic systems (e.g., dicalcium/tetracalcium phosphate mixtures) is its simpler, single solid phase formulation. When included as a component in appropriate resin-based composites, sealants and adhesives, ACP may be useful as a remineralization agent as well as a vehicle for sustained, controlled release of inorganic anticaries ions such as fluoride. In this regard, ACP-embedded, methacrylate resins release calcium and phosphate ions at levels that exceed the thermodynamic minimum necessary for remineralizing damaged tooth surfaces. The principal objective of this project is to maximize this remineralization potential by developing the most appropriate ACP/resin formulations for given dental applications and by evaluating their performance in vitro using bovine and human teeth in artificial saliva-like test milieus.

在这个项目中，无定形磷酸钙（ACP），这是一个重要的 正在研究磷灰石形成的中间体 可能用作牙科材料。当单独使用或在 与其他牙科材料，尤其是聚合物树脂的结合， ACP具有广泛的可能应用，例如恢复性 复合材料，腔衬里和碱，Luting和纸浆封盖剂， 预防性和牙髓密封剂，作为组件 牙周包和印象糊状。 它有很多 与其他磷酸钙相比的潜在优势 目的。 作为牙科水泥，它比当前双相的优势 系统（例如，二钙/四钙磷酸盐混合物）是它的 更简单，单个固相配方。 当包括 适当的基于树脂的复合材料，密封剂和 粘合剂，ACP可以用作回忆剂以及 持续，受控释放无机抗议的车辆 离子，例如氟化物。 在这方面，ACP被安装的甲基丙烯酸酯 树脂以超过的水平释放钙和磷酸离子 热力学的最低限度用于回忆牙齿受损的牙齿 表面。 该项目的主要目标是最大化 通过开发最合适的 给定牙科应用的ACP/树脂配方 使用牛和人牙在体外评估其性能 人造唾液状测试环境。