THE ANALYTICAL CHEMISTRY OF ANTI-AIDS AGENTS

抗艾滋病药物的分析化学

• 批准号: 3963224
• 负责人: J A KELLEY
• 金额: --
• 依托单位: DIVISION OF CANCER TREATMENT
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3963224
• 关键词: AIDS; analytical chemistry; antiAIDS agent; antiviral agents; chemical structure; chemical structure function; deoxyadenosines; deoxycytidine; drug design /synthesis /production; drug metabolism; gas chromatography; high performance liquid chromatography; immunopathology chemotherapy; mass spectrometry; nucleoside analog; pharmacology

The objective of this project is the research and development of suitable analytical methods to: (1) establish the structure and purity of potential anti-AIDS agents and new antiviral drugs, (2) determine physical and chemical properties of these compounds and their metabolites, and (3) measure these drugs and their metabolites in biological samples to elucidate pharmacology and to determine pharmacokinetics. Gas chromatography, high-performance liquid chromatography and mass spectrometry are emphasized techniques. Compounds of current interest are dideoxycytidine and dideoxyadenosine.

该项目的目的是研究和开发合适的 分析方法：（1）建立潜力的结构和纯度 抗AIDS剂和新的抗病毒药物，（2）确定物理和 这些化合物及其代谢物的化学特性，（3） 在生物样品中测量这些药物及其代谢物 阐明药理学并确定药代动力学。 气体 色谱，高性能液相色谱和质量 光谱法被强调。 当前兴趣的化合物是 二氧基胞苷和二氧添氧化物。