THE ANALYTICAL CHEMISTRY OF NEW ANTICANCER DRUGS

新抗癌药物的分析化学

• 批准号: 3874377
• 负责人: J A KELLEY
• 金额: --
• 依托单位: DIVISION OF CANCER TREATMENT
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3874377
• 关键词: analytical method; antineoplastics; cell differentiation; chemical structure function; cyclopentane; cytidine; cytosine nucleotides; drug design /synthesis /production; drug metabolism; drug screening /evaluation; gas chromatography; high performance liquid chromatography; mass spectrometry; neoplasm /cancer pharmacology; nitrogen mustard; nucleoside analog; oligonucleotides; pharmacokinetics; pyrimidine analog

The objective of this project is the research and development of analytical methods which are used to: (1) establish the structure and purity of new antitumor agents and their metabolites, (2) determine physical and chemical properties of new anticancer drugs, (3) quantitate drugs and their metabolites in biological samples to elucidate pharmacology and to determine pharmacokinetics, and (4) study reaction mechanisms of potentially useful synthetic transformations. Mass spectrometry, gas chromatography and high-performance liquid chromatography, either alone or in combination, are emphasized techniques. Compounds of current interest are cyclopentenyl cytosine (biochemistry, preclinical pharmacology and methods development), carbodine/ isocarbodine (synthesis and analytical characterization), hexamethylene bisacetamide (tablet bioequivalence and pharmacokinetics) and modified nucleosides (analytical characterization).

该项目的目的是分析的研究和开发 用于以下方法：（1）建立新的结构和纯度 抗肿瘤剂及其代谢物，（2）确定物理和化学 新抗癌药物的特性，（3）定量药物及其特性 生物样品中的代谢物，以阐明药理学和 确定药代动力学和（4）研究的反应机制 潜在有用的合成转换。质谱法，气体 单独或 结合使用，强调了技术。当前兴趣的化合物 是环戊烯基胞嘧啶（生物化学，临床前药理学和 方法开发），碳纤维/异橄榄石（合成和分析 表征），六甲基双乙酰胺（片剂生物等效性和 药代动力学）和修饰的核苷（分析表征）。