IRON-57 AND H-2 NUCLEAR MAGNETIC RESONANCE--NEW TOOLS FOR BIOMEDICAL RESEARCH

IRON-57和H-2核磁共振--生物医学研究的新工具

• 批准号: 3939519
• 负责人: O A GANSOW
• 金额: --
• 依托单位: DIVISION OF CANCER TREATMENT
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3939519
• 关键词: clinical biomedical equipment; cytochromes; deuterium; ferredoxin; hemoglobin; myoglobin; neoplasm /cancer radionuclide diagnosis; nuclear magnetic resonance spectroscopy; porphyrins

We are developing iron-57 and deuterium Nuclear Magnetic Resonance (NMR) as an experimental method for use in the Biomedical Sciences. Many compounds found in the blood contain iron cores. Among these are the cytochromes, hemoglobin, or ferridoxin. Few chemical methods may be used to directly study the central metal atom environments of these proteins. Iron-57 NMR is being developed for that purpose. Some time ago, we reported the utility of iron-57 NMR for study of relaxation times and chemical shifts of some iron compounds related to biological entities. We determined thus the basic parameters needed for further study of iron NMR. Our current efforts to extend this project to include an examination of the field dependent H-2 NMR of iron porphyrins as a companion method to iron NMR have resulted in measurements of anisotropies on iron porphyrins partially oriented in a magnetic field.

我们正在开发Iron-57和氘核磁 共振（NMR）作为实验方法 生物医学科学。 血液中发现的许多化合物 包含铁芯。 其中包括细胞色素， 血红蛋白或铁毒素。 很少可以使用化学方法 直接研究其中的中央金属原子环境 蛋白质。 Iron-57 NMR正在为此目的开发。 不久前，我们报道了铁-57 NMR的效用 一些铁化合物的放松时间和化学移位 与生物实体有关。 因此，我们确定了基本 进一步研究铁NMR所需的参数。 我们目前为扩展该项目以包括一个 检查卟啉铁的H-2 NMR场的检查 作为铁NMR的伴侣方法已导致 对铁卟啉的各向异性的测量部分 定向在磁场中。