RADIONUCLIDE GENERATORS TO PRODUCE THE IRIDIUM-194 BETA EMITTER

用于生产铱 194 Beta 发射体的放射性核素发生器

• 批准号: 3874417
• 负责人: O A GANSOW
• 金额: --
• 依托单位: DIVISION OF CANCER TREATMENT
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3874417
• 关键词: beta radiation; biomedical equipment safety; clinical biomedical equipment; gamma radiation; iridium; neoplasm /cancer radiodiagnosis; neoplasm /cancer radionuclide therapy; neutron radiation; nuclear medicine; osmium; radiation dosage; radionuclide imaging /scanning; radionuclides; radiopharmacology; radiotracer

The project investigates the design, manufacturing, testing, and use of a novel radionuclide generator for biomedical applications. The generator has a long shelf-half-life, many years, and produces a 20-hour radionuclide daughter which emits high-energy beta particles that have suitable characteristics for labelling proteins through bifunctional chelates. In the 194-Os/1 94-Ir generator containing the parent nuclei, 194-Os has a halflife of 6.0 years which beta-decays, EmaxB=100 KeV, to the 19.15-hour 194-Ir daughter. The 194-Ir daughter decays with the emission of 2.2 MeV beta particles to the ground state of 194-Pt (86%) and to the 328.5 KeV first excited state with emission of 1.9 MeV beta particles (9.2%). There is a 328.5 KeV gamma-ray which follows the decay of 194-Ir with 13% absolute aboundance. The absence of high intensity gamma-rays in the decay of 194-Ir, with the exception to the 328.5 KeV, makes this beta emitter nuclei very attractive from the point of view of dosimetric considerations. On the other hand, the presence of 328.5 KeV gamma-rays makes 194-Ir a superior nuclei to 90-Y for tumor imaging. This year, Dr. Mirzadeh moved from the NIH to Oak Ridge National Laboratory where he has now completed work on the lridium-194 radionuclidic generator.

该项目研究了一种产品的设计、制造、测试和使用。 用于生物医学应用的新型放射性核素发生器。发电机有 保质半衰期长，长达多年，并产生 20 小时的放射性核素 子体发射高能β粒子，具有合适的 通过双功能螯合物标记蛋白质的特征。 在含有母核的 194-Os/1 94-Ir 发生器中，194-Os 有一个 半衰期为 6.0 年，β 衰变，EmaxB=100 KeV，至 19.15 小时 194-我的女儿。 194-Ir 子体衰变，发射能量为 2.2 MeV β 粒子达到 194-Pt 基态 (86%) 和 328.5 KeV 第一激发态发射 1.9 MeV β 粒子 (9.2%)。那里 是 328.5 KeV 伽马射线，跟随 194-Ir 衰变 13% 绝对丰富。衰变过程中不存在高强度伽马射线 194-Ir（除 328.5 KeV 外）使得该 β 发射体 从剂量学考虑的角度来看，原子核非常有吸引力。 另一方面，328.5 KeV 伽马射线的存在使得 194-Ir 成为 优于 90-Y 的细胞核用于肿瘤成像。 今年，Mirzadeh 博士从 NIH 转到橡树岭国家实验室 他现已在那里完成了铱194放射性核素发生器的工作。