Core Equipment to underpin the National Crystallography Service 2020-

支撑国家晶体学服务2020的核心设备-

• 批准号: EP/V032992/1
• 负责人: Simon Coles
• 金额: $ 53.67万
• 依托单位: University of Southampton
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2020
• 资助国家: 英国
• 起止时间: 2020 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=EP%2FV032992%2F1
• 关键词: Core; Equipment; underpin; National; Crystallography

The strategy in answering this call is to provide a balanced approach to secure essential replacement equipment with a forward-looking component and this is achieved by bringing together the two strands of 'invest to save' and 'underpinning multi-user equipment'. Coupled with established routes to supporting and enabling ECRs and doctoral students, the National Crystallography Service (NCS) is able to touch on all the Core Equipment call objectives.The NCS is a world-renowned facility with a large user base and was the first National Research Facility to be established (1981). This NRF is ideally suited to maximising the benefits and beneficiaries of a Core Equipment investment, being an advanced facility with a national reach and an established, coordinated approach to maintaining and expanding its user base. The NRF model provides the access mechanisms, expert support, monitoring, governance and sustainable operating model to ensure that this investment will be fully realised to its maximum potential.The main equipment item, a new goniometer, has been identified through involving the formal governance and review procedures of the NCS. It is therefore a truly key equipment component that is at risk and its replacement will enable a continued high level of performance and throughput of the NCS. The continued delivery of NCS core business at a high standard will be supported by the introduction of a high-powered microscope which will provide new capability as well as more redundancy and higher throughput. The other two items of equipment, an Intelligent Goniometer Head and a cryostat, will support the technique development aspect of the NCS. The former will provide an entirely new approach to mitigating against sample decay and would be developed with the instrument manufacturer. The latter will complete a £400k equipment loan to underpin an entirely new capability based around the crystal sponge technique. This endeavour is a joint development/impact project partnering with Merck and Rigaku companies, which would enable acquisition of structural data on nanolitres of material or substances that don't readily crystallise. The aim is for this to become a new component of the NCS service provision and with strategic partnerships already in place, it will develop and significantly impact new crystallography user communities in academia and industry. The unique position and reach of the NCS in the community will enable maximisation of the number of beneficiaries of this equipment investment through its core business, advanced methods and technique development work. The large established user base reaches through to PhD students and ECRs - all of whom would have opportunity for skills training provided with this equipment. In conclusion, with the ability to continue to sustain the high level of service provision, the NCS can also add significant value to this investment through well-established routes and clearly identified pathways to impact via partnerships with key industry and instrument manufacturers.

响应这一号召的策略是提供一种平衡的方法来确保具有前瞻性组件的基本更换设备，这是通过将“投资节省”和“支持多用户设备”这两条链结合在一起来实现的。国家晶体学服务中心 (NCS) 建立了支持和支持 ECR 和博士生的路线，能够触及所有核心设备调用目标。NCS 是世界知名的设施，拥有庞大的用户群，是第一个国家研究设施该 NRF 非常适合最大化核心设备投资的利益和受益者，它是一个覆盖全国的先进设施，并提供了一种既定的、协调的方法来维护和扩大其用户群。准入机制、专家支持、监测、治理和可持续运营模式，以确保这项投资充分发挥其最大潜力。主要设备项目是一种新的测角仪，已通过 NCS 的正式治理和审查程序确定因此它是一个真正的。存在风险的关键设备组件及其更换将使 NCS 能够持续保持高水平的性能和吞吐量 高标准的 NCS 核心业务的持续交付将得到高性能显微镜的支持，该显微镜将提供新功能以及更多的冗余和更高的吞吐量。另外两项设备，即智能测角仪头和低温恒温器，将支持 NCS 的技术开发，前者将提供一种全新的方法来减轻样品衰减和影响。将被开发后者将完成一项 40 万英镑的设备贷款，以支持基于晶体海绵技术的全新能力。这项工作是与默克 (Merck) 和 Rigaku 公司合作的联合开发/影响项目，将能够获取结构数据。其目标是成为 NCS 服务提供的新组成部分，并且通过已经建立的战略合作伙伴关系，它将发展并显着影响新的晶体学用户社区。 NCS 在学术界和工业界的独特地位和影响力将通过其核心业务、先进方法和技术开发工作，使该设备投资的受益者数量最大化。 ECR - 所有这些人都有机会接受使用该设备提供的技能培训。 总之，由于有能力继续维持高水平的服务提供，NCS 还可以通过完善的路线和明确的方式为这项投资增加显着的价值。确定了通过与关键行业的伙伴关系产生影响的途径仪器制造商。