X-RAY FLOURESCENCE SPECTROMETER SYSTEM

X 射线荧光光谱仪系统

• 批准号: 3519960
• 负责人: ROBERT F MATTREY
• 金额: $ 12.5万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN DIEGO
• 依托单位国家: 美国
• 财政年份: 1988
• 资助国家: 美国
• 起止时间: 1988-04-04 至 1989-04-03
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3519960
• 关键词: X ray spectrometry; biomedical equipment purchase; computer graphics /printing; elements; fluorescence spectrometry; histology

Research programs often make significant advancements when appropriate new analytical and experimental procedures are developed. We have developed and X-ray fluorescence technique for measuring elements in biological tissues that will provide advanced analytical capability which previously has not been possible. To take full advantage of this achievement, we are requesting funds for the purchase of an X-Ray Fluorescence (XRF) Spectrometer system. In the basic operation of an XRF spectroscopy system, a photon bombardment of the sample produces X-rays characteristic for each element which pass through a beryllium window of the sample, strike a detector and are analyzed by a multichannel analyzer. This instrument detects all elements with mol wt greater than 19. The principle investigator developed new techniques utilizing a KEVEX 0700 XRF spectrometer for detecting and quantitating several elements in concentrations greater than 10 umolar, either separately or simultaneously, in various biological tissues. With these technical advances in sample preparation, XRF spectroscopy will simplify many analytical procedures which are now quite tedious and expensive in terms of time and resources. The primary need for the XRF system in our research laboratories is to gain 100% access to the equipment. This instrument will be used in NIH projects related to the development of new contrast enhancement agents for MRI, CT and ultrasonography and for developing new non-invasive MRI diagnostic and physiologic techniques. Current access to the one XRF system in the San Diego region (North Island Naval Base) is limited, inconvenient, terribly inefficient and severely restrictive to the progress of our NIH research programs. When accessible, the XRF system is still only available for a small fraction of the time needed to take full advantage of this technology for our NIH programs. Because of the instrument's versatility and the technical advances we are making in sample preparation, this XRF system will be useful for many years. It will remain an ideal core instrument, suitable for today's important NIH-sponsored projects while flexible enough to be relevant for future projects --- an invaluable tool for reaching today's and tomorrow's research goals.

研究计划通常在 适当的新分析和实验程序是 发达。 我们已经开发了X射线荧光技术 用于测量生物组织中的元素 高级分析能力，以前尚未 可能的。 为了充分利用这项成就，我们是 要求购买X射线荧光的资金 （XRF）光谱仪系统。 在XRF的基本操作中 光谱系统，样品的光子轰击 为通过的每个元素生成X射线特征 通过样品的铍窗口，打击探测器和 由多通道分析仪分析。 该仪器检测到 所有摩尔WT的元素都大于19。 原则研究者开发了利用一种新技术 Kevex 0700 XRF光谱仪用于检测和定量 浓度大于10 Umolar的几个元素，既可以 分别或同时在各种生物组织中。 和 样品制备方面的这些技术进步，XRF 光谱法将简化许多分析程序 在时间和资源方面，现在非常乏味和昂贵。 我们的研究实验室中XRF系统的主要需求 是100％访问设备。 这个乐器将是 用于与新对比的发展有关的NIH项目 MRI，CT和超声检查的增强剂以及 开发新的非侵入性MRI诊断和生理学 技术。 当前访问SAN中的一个XRF系统 迭戈地区（北岛海军基地）有限，不便， 效率低下，严重限制了我们的进步 NIH研究计划。 当访问时，XRF系统仍在 仅用于满足满足时间的一小部分时间 这项技术在我们的NIH计划中的优势。 由于乐器的多功能性和技术进步 我们正在制定样品准备，此XRF系统将是 多年来有用。 它将仍然是理想的核心工具， 适用于当今重要的NIH赞助的项目 灵活足以与未来的项目相关---宝贵的 达到今天和明天的研究目标的工具。