MINORITY HIGH SCHOOL STUDENT RESEARCH APPRENTICE PROGRAM

少数民族高中生研究学徒计划

• 批准号: 3511743
• 负责人: LEONARD E LAWRENCE
• 金额: $ 1.5万
• 依托单位: UNIVERSITY OF TEXAS HLTH SCIENCE CENTER
• 依托单位国家: 美国
• 财政年份: 1982
• 资助国家: 美国
• 起止时间: 1982-03-01 至 1992-02-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3511743
• 关键词: minority institution research support; secondary schools

This proposal requests funds to modify and upgrade and existing cyclotron facility at Memorial Sloan - Kettering Cancer Center (MSKCC). The cyclotron, a Cyclotron Corp. Model CS-15, produces short-lived, posltron-emitting radionuclides essential for imaging and tissue radioassay studies by three funded PHS- supported grants and a funded Department of Energy Grant. The present proposal is designed to ensure ongoing development of the cyclotron as a key resource for investigation of tumor growth, metabolism and response to treatment, as well as the physiology and metabolism of non-malignant tissues and organs of the tumor- bearing host. Funding is requested for the major pieces of equipment required for the proposed upgrade (items 1 -5 below). The specific aims are: 1. Replacement of cyclotron magnet coils. 2. Replacement of present cyclotron harmonic coils with a modern harmonic coil-centering coil combination and replacement of coil power supplies. 3. Improvement of cyclotron ion source by replacement of power supply and improvement of positioning mechanism. 4. Implementation of system for remote change of cyclotron frequency. 5. Modification of the two existing radiochemical hot cells to create a third hot cell in order to facilitate simultaneous use. 6. Installation of devices (extraction probe and exit slits) for monitoring of parameters affecting cyclotron beam extraction efficiency. 7. Repair of cyclotron helium -3 recovery system. 8. Improvement of cyclotron vacuum by repair of leaks inaccessible without major disassembly of cyclotron. 9. Implementation of radiation detection system within hot cells to permit step-by-step monitoring of yields in radiosynthetic processes. These improvements will enhance the operation of the Cyclotron Facility by increasing the time available for cyclotron bombardment and improving the efficiency of the radiochemical hot laboratory. The proposed upgrade is required to meet the needs of the funded users and to promote pilot studies for new users, as well as to provide opportunities for researchers from neighboring scientific institutions.

该建议要求资金修改和升级和现有 纪念斯隆的回旋设施 - 凯特林癌症中心 （MSKCC）。 Cyclotron，Cyclotron Corp. CS-15型， 产生短寿命的POSLTRON发射放射性核素 三个资助的PHS的成像和组织射线测定研究 支持赠款和资助的能源部赠款。 这 目前的建议旨在确保持续的发展 回旋子作为研究肿瘤生长的关键资源， 代谢和对治疗的反应以及生理学 以及肿瘤非恶性组织和器官的代谢 轴承主持人。 要求为主要部分提供资金 拟议升级所需的设备（下面的第1-5项）。 具体目的是： 1。替换回旋磁铁线圈。 2。用A代替当前的回旋谐波线圈 现代谐波线圈中心线圈组合和 更换线圈电源。 3。通过替换改善回旋离子源 电源和定位机制的改进。 4。实施用于远程变更的系统 频率。 5。对两个现有放射性热细胞的修改 创建第三个热单元以促进同时 使用。 6。安装设备（提取探针和出口缝隙） 监视影响回旋光束的参数 提取效率。 7。回收系统的回收系统的修复。 8。通过修复泄漏来改善回旋器真空 无法访问，而没有重大的回旋子拆卸。 9。在热内实施辐射检测系统 细胞允许逐步监测产量 放射合成过程。 这些改进将增强回旋子的运行 通过增加回旋子的时间来增加设施 轰炸并提高放射化学的效率 热实验室。 提出的升级需要满足 资金用户的需求并促进新的新型研究 用户以及为研究人员提供机会 邻近的科学机构。