PULMONARY EFFECTS OF MACHINING FLUID AEROSOLS

加工液气溶胶对肺部的影响

• 批准号: 3421076
• 负责人: Terry Gordon
• 金额: $ 9.8万
• 依托单位: NEW YORK UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1993
• 资助国家: 美国
• 起止时间: 1993-09-01 至 1995-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3421076
• 关键词: acidity /alkalinity; aerosols; bronchial mucus; diagnostic respiratory lavage; disease /disorder model; disease /disorder proneness /risk; endotoxins; environmental toxicology; fluid; guinea pigs; lung injury; occupational hazard; pollution related respiratory disorder; statistics /biometry

This proposal is part of a continued effort to examine the role of inflammatory cells and mediators in the airway injury produced by inhalation of environmental and occupational agents. This research proposal will examine the acute and subchronic pulmonary effects of machining fluid aerosols - an occupational hazard for nearly 1 million workers in this country. Machining fluids/cutting oils are hypoosmolar, alkaline fluids which are frequently contaminated with a variety of microbial agents. The major goals of the proposed studies are to 1) determine the roles of contaminating endotoxin, hypotonicity, and alkalinity in the adverse pulmonary effects associated with occupational exposure to machining fluid aerosols; and 2) compare the potential of different classes of machining fluids to produce inflammatory and functional changes in the lung. Adverse pulmonary effects after single and repeated exposures to machining fluid aerosols will be examined using functional, biochemical, and morphological techniques in a sensitive guinea pig model. Thus, the proposed studies will determine whether subclinical inflammatory changes persist in the lung after repeated exposure to machining fluid aerosols at exposure concentrations near the current TLV. The proposed experiments will help to provide a clearer understanding of the role of microbial contamination in the pulmonary effects of inhaled machining fluid aerosols.

该提议是持续努力的一部分，以研究 气道损伤中的炎症细胞和介体由 吸入环境和职业代理商。 这项研究 提案将检查急性和亚基肺的影响 加工流体气溶胶 - 一种职业危害近100万 这个国家的工人。 加工液体/切割油是低增压的， 碱性液经常被多种污染 微生物剂。 拟议研究的主要目标是1） 确定污染内毒素，低音性和 与职业相关的不良肺作用的碱度 暴露于加工液气溶胶； 2）比较 不同类别的加工流体以产生炎症和 肺的功能变化。 单一后肺部不良影响 并重复使用加工流体气溶胶的曝光 敏感的功能性，生化和形态学技术 豚鼠模型。 因此，拟议的研究将确定是否 重复后，肺中的亚临床炎症变化持续存在 在接触浓度附近的暴露浓度下接触加工流体气溶胶 当前TLV。 提出的实验将有助于提供更清晰的 了解微生物污染在肺中的作用 吸入加工液气溶胶的影响。