Acute and Chronic In vivo Effects of Engineered Nanomaterials

工程纳米材料的急性和慢性体内效应

• 批准号: 8663595
• 负责人: Terry Gordon
• 金额: $ 51.8万
• 依托单位: NEW YORK UNIVERSITY SCHOOL OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-09-24 至 2016-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8663595
• 关键词: Acute; Address; Apoptosis; Breathing; Cardiovascular system; Cell Differentiation process; Cell Proliferation; Cerium; Chronic; Development; Discipline of obstetrics; Engineering; Exposure to; Hepatic; Low Birth Weight Infant; Lung; Malignant - descriptor; Modeling; Molecular; Nickel; Organ; Process; Relative (related person); Silver; Testing; Toxic effect; age effect; aged; biological adaptation to stress; fetal; in vivo; nanomaterials; nanoparticle

This research project focuses on the role of physical-chemical characteristics of nanoparticles in their interactions with cells, organelles, and organs after in vivo exposure via the inhalation route. During the first year, we will assess the biokinetics and toxicity of 3 selected nanoparticles under three different physical-chemical states. An important goal of our research will be the evaluation of acute vs. chronic toxicity of inhaled nanoparticles. We propose to compare the acute and chronic toxicity in test animals exposed by inhalation to cerium, nickel, and silver nanoparticles. Each of these commercially-important nanomaterials (and other Consortium-selected nanomaterials) will be dynamically generated for these inhalation studies. The nose-only exposure system has been constructed and the nanoparticle generation system is almost complete (as of 2/11). Tasks completed include: 1. testing of furnace system to fully oxidize aged nanoparticles 2. construction ofthe aging system in the animal housing facility 3. ordering of test material for nanoparticle generation 4. recruitment of an exposure assessment student to participate in the research for his Master's thesis

该研究项目的重点是通过吸入途径在体内暴露后，纳米颗粒与细胞，细胞器和器官的相互作用中的物理化学特征的作用。在第一年，我们将评估在三种不同的物理化学状态下的3种选定纳米颗粒的生物动力学和毒性。 我们研究的一个重要目标是评估吸入纳米颗粒的急性毒性与慢性毒性。我们建议比较通过吸入葡萄，镍和银纳米颗粒暴露于测试动物中的急性和慢性毒性。这些吸入研究将动态生成这些商业上最重要的纳米材料（和其他联盟选择的纳米材料）。仅鼻子暴露系统已经构建，纳米颗粒的生成系统几乎完整（截至2/11）。完成的任务包括： 1。测试炉系统以完全氧化老化的纳米颗粒 2。在动物住房设施中建造老化系统 3。纳米颗粒产生的测试材料排序 4。招募曝光评估学生参加硕士论文的研究

项目成果

Aerosolized Silver Nanoparticles in the Rat Lung and Pulmonary Responses over Time.

• DOI: 10.1177/0192623316629804
• 发表时间: 2016-07
• 期刊: Toxicologic pathology
• 影响因子: 1.5
• 作者: Silva RM;Anderson DS;Peake J;Edwards PC;Patchin ES;Guo T;Gordon T;Chen LC;Sun X;Van Winkle LS;Pinkerton KE
• 通讯作者: Pinkerton KE