VASOPRESSIN AND FLANK MARKING BEHAVIOR

加压素和侧翼标记行为

• 批准号: 3407191
• 负责人: Craig F Ferris
• 金额: $ 14.82万
• 依托单位: UNIV OF MASSACHUSETTS MED SCH WORCESTER
• 依托单位国家: 美国
• 财政年份: 1986
• 资助国家: 美国
• 起止时间: 1986-08-01 至 1990-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3407191
• 关键词: afferent nerve; aggression; animal communication behavior; behavior test; brain mapping; chemical structure function; efferent nerve; ethology; experimental brain lesion; histochemistry /cytochemistry; hormone regulation /control mechanism; immunochemistry; kainate; microinjections; neuroendocrine system; neuropsychology; neurotoxins; neurotransmitters; olfactions; peptide hormone analog; preoptic areas; sex behavior; social behavior; social dominance; vasopressins

Flank marking, a form of olfactory communication in Golden hamsters (Mesocricetus auratus) is dependent upon a vasopressin-sensitive pathway in the medial preoptic area (MPOA) of the hypothalamus. Vasopressin (VP) microinjected into a discrete site of the MPOA reliably elicits intense bouts of flank marking and an antagonist to vasopressin injected into the same site inhibits flank marking induced by microinjection of VP or the odors of other hamsters. Studies have been proposed to define the afferent and efferent connections of the area within the MPOA controlling flank marking behavior by horseradish peroxidase histochemistry. Once identified, these sensory and motor connections will be lesioned to determine their relevance in the expression of flank marking. The concentration of VP within the effective site of the MPOA will be determined by chromatographic and immunochemical methods and the binding characteristics of VP within this site will be determined by Scatchard analysis. Various analogs and metabolites of VP will be microinjected into the MPOA to study the structure-activity relationship between VP and flank marking. Finally, a series of studies will be conducted to investigate the function of flank marking behavior in specific social situations (i.e. aggressive and reproductive interactions). In summary, vasopressin-dependent flank marking in the MPOA provides an excellent model system for studying the neuroanatomy and chemistry involved in the organization and expression of a complex communicative behavior. Defining the anatomical and neurochemical bases of a mammalian behavior should eventually lead to a better understanding of normal and abnormal human behavior.

侧翼标记，金仓鼠嗅觉交流的一种形式 （Mesocricetus auratus）依赖于加压素敏感途径 下丘脑内侧视前区（MPOA）。 加压素 (VP) 显微注射到 MPOA 的离散位点可靠地引发强烈 侧腹标记和注射抗利尿激素拮抗剂的发作 同一位点抑制显微注射 VP 或 其他仓鼠的气味。 已提出研究来定义传入 MPOA 控制侧区域内的传出连接和传出连接 辣根过氧化物酶组织化学标记行为。 一次 一旦确定，这些感觉和运动连接将受到损害 确定它们在侧面标记表达中的相关性。 这 MPOA 有效位点内的 VP 浓度为 通过色谱法和免疫化学方法测定和结合 本网站内 VP 的特征将由 Scatchard 确定 分析。 VP的各种类似物和代谢物将被显微注射到 MPOA研究VP和侧翼之间的构效关系 标记。 最后，将进行一系列研究来调查 侧翼标记行为在特定社会情境中的功能（即 攻击性和生殖性相互作用）。 总之， MPOA 中加压素依赖性侧翼标记提供了一个出色的模型 研究神经解剖学和化学的系统 复杂交际行为的组织和表达。 定义 哺乳动物行为的解剖学和神经化学基础应该 最终导致更好地理解正常和异常人类 行为。