Imaging Core

成像核心

• 批准号: 7984287
• 负责人: Craig F Ferris
• 金额: $ 14.75万
• 依托单位: NORTHEASTERN UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-09-01 至 2015-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7984287
• 关键词: Animal Disease Models; Biodistribution; Data; Data Analyses; Data Storage and Retrieval; Detection; Diagnostic; Disease model; Faculty; Functional Imaging; Housing; Human Resources; Image; Imagery; Intervention; Intervention Studies; Kinetics; Label; Libraries; Longitudinal Studies; Measurement; Metric; Modeling; Monitor; Online Systems; Organ; Pharmaceutical Preparations; Positron-Emission Tomography; Property; Protocols documentation; Radio; Research Personnel; Resolution; Schedule; System; Therapeutic Intervention; Time; Universities; base; data acquisition; disease diagnosis; drug development; experience; in vivo; instrumentation; neuroimaging; novel; oncology; pre-clinical; protocol development; repository; single photon emission computed tomography; tumor

Imaging Core The imaging capabilities at the Center for Translational Neuroimaging at Northeastern University offer unique capabilities for the visualization of nanopreparations in vivo. The center currently houses a high-resolution microSPECT/CT (NanoSPECT/CT, Bioscan, Inc.) and a 7T MR system (BioSpec, Bruker Biospin, Inc.) with a microPET to be installed in Q4 of this year. With extensive experience in onco-based imaging protocols, the imaging core enables the assessment of kinetics and dynamics of radio-labeled nanopreparations via SPECT and PET as well as nanopreparations for contrast enhanced MR studies. Multi-modal data acquisition support projects in drug development, intervention monitoring, disease diagnosis and tracking, and functional imaging. In addition to instrumentation and protocol development, the core offers a library of analysis functions for longitudinal studies of animal models of disease. Such functionality focuses on the tracking of nanopreparations via standard in vivo and ex vivo biodistribution analysis as well as novel sub-organ and sub-tumor metrics of distribution. The core hosts data and analysis results on a web-based data storage and analysis center dedicated to pre-clinical longitudinal imaging studies. Faculty and collaborating researchers have real-time access to data via the web-based repository along with remote scheduling and study-planning capabilities.

成像核心 东北大学转化神经影像中心的成像能力 为体内纳米制剂的可视化提供独特的功能。该中心目前拥有高分辨率 microSPECT/CT（NanoSPECT/CT，Bioscan, Inc.）和 7T MR 系统（BioSpec, Bruker Biospin, Inc.）将于今年第四季度安装 microPET。凭借丰富的经验 基于 onco 的成像方案，成像核心能够通过 SPECT 和 PET 评估放射性标记纳米制剂的动力学和动力学，以及用于对比的纳米制剂 增强 MR 研究。多模态数据采集支持药物开发、干预监测、疾病诊断和跟踪以及功能成像等项目。除了仪器和协议开发之外，该核心还提供了用于疾病动物模型纵向研究的分析功能库。此类功能侧重于通过标准体内和离体生物分布分析以及新颖的亚器官和亚肿瘤分布指标来跟踪纳米制剂。 该核心在专门用于临床前纵向成像研究的基于网络的数据存储和分析中心上托管数据和分析结果。教师和合作研究人员可以通过基于网络的存储库实时访问数据以及远程调度和研究计划功能。