BRAIN FUNCTION IN SOCIAL AFFILIATION AND PARENTAL MOTIVATION

社会归属和父母动机中的大脑功能

• 批准号: 7716450
• 负责人: Craig F Ferris
• 金额: $ 4.1万
• 依托单位: UNIVERSITY OF WISCONSIN-MADISON
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-07-23 至 2009-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7716450
• 关键词: Adult; Animals; Brain; Callithrix; Computer Retrieval of Information on Scientific Projects Database; Crossover Design; Data; Female; Functional Magnetic Resonance Imaging; Funding; Grant; Hemorrhage; Hydrocortisone; Infant; Institution; Methods; Motivation; Partner in relationship; Research; Research Personnel; Resources; Serum; Services; Source; Stimulus; Testosterone; United States National Institutes of Health; awake; brain pathway; male; olfactory stimulus; social; stimulus processing; Adult; Animals; Brain; Callithrix; Computer Retrieval of Information on Scientific Projects Database; Crossover Design; Data; Female; Functional Magnetic Resonance Imaging; Funding; Grant; Hemorrhage; Hydrocortisone; Infant; Institution; Methods; Motivation; Partner in relationship; Research; Research Personnel; Resources; Serum; Services; Source; Stimulus; Testosterone; United States National Institutes of Health; awake; brain pathway; male; olfactory stimulus; social; stimulus processing

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. To investigate brain pathways involved in mate affiliation and parental motivation. Functional magnetic resonance imaging (fMRI) is carried out on awake male marmosets while they are presented with isolated scents from (familiar vs. unfamiliar) adult females and infants. We have developed methods to present the olfactory stimuli to the male marmosets from both female scents (Ziegler et al., 2005) and from infant scents. Seven male marmosets were presented with scents from their own infants during a 10-minute presentation while the males were in isolation. Males were bled 30 minutes after the onset of the presentation and serum was analyzed for testostereone and cortisol. In a crossover design, males were presented with either their own infants' scents or a vehicle control scent. Males showed a significant decrease in testosterone levels after interacting with the infant scent whereas testosterone following presentation of the control stimulus did not alter from normal testosterone levels for male adult marmosets. Cortisol levels were not significantly different between the infant scent and the vehicle control. These data indicate that male marmosets are responsive to infant stimuli and that the scent stimuli are processed in the brains of the males. This research used WNPRC Animal Services.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 调查与伴侣隶属关系和父母动机有关的大脑通路。 功能性磁共振成像（fMRI）是在清醒的雄性果棒上进行的，而它们则来自（熟悉的与熟悉的）成年女性和婴儿的孤立气味。 我们已经开发了将两种雌性气味的雄性果酱呈现嗅觉刺激的方法（Ziegler等，2005）和婴儿香气。 在10分钟的演讲中，在雄性孤立的情况下，在10分钟的演讲中向自己的婴儿带来了七个雄性mar豆。 演示开始后30分钟，将雄性分为BL，并分析血清中的睾丸激素和皮质醇。 在跨界设计中，雄性出现了自己的婴儿的气味或车辆控制气味。 雄性与婴儿气味相互作用后显示出睾丸激素水平的显着降低，而对照刺激表示对照刺激后的睾丸激素并未改变雄性成年果mo虫的正常睾丸激素水平。 婴儿气味和车辆控制之间的皮质醇水平没有显着差异。 这些数据表明，雄性果mo虫对婴儿刺激有反应，并且在男性的大脑中处理气味刺激。这项研究使用了WNPRC动物服务。