Molecular Neurogenetics of Olfactory Driven Aggression and Social Hierarchy in a Model Insect System

模型昆虫系统中嗅觉驱动的攻击性和社会等级的分子神经遗传学

基本信息

批准号：
10170383
负责人：
LAURENCE J ZWIEBEL
金额：
$ 31.39万
依托单位：
VANDERBILT UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2018
资助国家：
美国
起止时间：
2018-08-16 至 2024-04-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10170383
关键词：
Adult Aggressive behavior Animal Model Animals Ants Automobile Driving Behavior Behavioral Behavioral Model Behavioral Paradigm Behavioral Research Biological Assay Biological Models Brain Castes Chemicals Clustered Regularly Interspaced Short Palindromic Repeats Collection Communication Complex Data Set Drosophila melanogaster Economics Ethics Exhibits Family Female Florida Gene Targeting Gland Hemolymph Human Hydrocarbons Individual Insecta Knock-out Light Link Mammals Mediating Messenger RNA Modeling Molecular Neuraxis Neurobiology Neuronal Plasticity Neuropeptides Odorant Receptors Olfactory Pathways Pathway interactions Pattern Peripheral Pheromone Pheromone Receptors Police Primates Proteomics Publishing RNA Interference Research Role Smell Perception Social Behavior Social Hierarchy Social status Sterility System Tachykinin Testing Transgenic Organisms Triad Acrylic Resin base behavioral plasticity behavioral response behavioral study bioinformatics pipeline gain of function human model loss of function male mutant neurogenetics neuropeptide F programs receptor reproductive response social synthetic peptide transcriptome sequencing transcriptomics

项目摘要

Project Summary Humans and many other animals exhibit a wide variety of social behaviors. Traditionally, primates have been used as research models of human behavior due to their close evolutionary relationship to humans and their highly social behavior. However, the use of primates for such research has significant economic, practical, and ethical drawbacks, and, in that light, it would be useful to find other models for behavioral studies that exhibit complex social behaviors. One potential model that fits both criteria is the extensive family of insects collectively known as the ants, some species of which exhibit highly complex “eusocial” behaviors involving a strict division of labor between sterile workers and reproductive queens. Among ant workers, there is a further division of labor, with different tasks allocated among different castes of workers. Our hypothesis is that caste/colony-specific aggression and social hierarchy reflect and in-part are determined by chemosensory programs dictated largely through odorant receptors and shifts in neuropeptidomic profiles. We will investigate this question in two ant species—Camponotus floridanus and Harpegnathos saltator—that exist in large colonies that are composed of just a few males, and the remainder are females, including one (typically) queen, and numerous workers that engage in caste/colony specific aggressive behaviors such as defense, policing and dueling.

项目摘要人类和许多其他动物表现出各种各样的社会行为。由于与人类的紧密进化关系，用作人类行为的研究模型但是，高度社会行为。道德上的缺点，从那时起，找到其他表现的行为研究模型将很有用复杂的社会行为。统称为蚂蚁，其中一些物种表现出高度复杂的“ eusocial”行为，涉及无菌工人与生殖皇后之间的严格离婚。劳工分工，在不同的工人中分配了不同的任务。我们的假设是，种姓/殖民地特异性的养育和社会等级制度反映和部分是确定的通过化学感应程序决定了很大程度上的三个受体和神经肽谱的变化。我们将在两个蚂蚁物种中调查这个问题-Camponotus floridanus和Harpegnathos saltator- 存在于仅由几个男性组成的大殖民地中（通常）女王，众多从事种姓/殖民地特定侵略行为的工人，例如防御，警务和决斗。