NEUROPHYSIOLOGICAL STUDY OF DORSAL SPINOCEREBELLAR TRACT

脊髓小脑背侧束的神经生理学研究

• 批准号: 3402000
• 负责人: RICHARD E POPPELE
• 金额: $ 10.43万
• 依托单位: UNIVERSITY OF MINNESOTA
• 依托单位国家: 美国
• 财政年份: 1985
• 资助国家: 美国
• 起止时间: 1985-09-09 至 1993-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3402000
• 关键词: afferent nerve; cats; cerebellum; decerebration; dorsal column; electrophysiology; electrostimulus; limb movement; neural information processing; neural transmission; neurogenesis; sensorimotor system; sensory mechanism; single cell analysis; stretch reflex

The proposed research is a program for an in-depth neurophysiological study of the dorsal spinocerebellar tract (DSCT) in the cat. The long term objectives of the program are to determine the role played by sensory receptors in the control of movement and posture. The DSCT is a pathway that transmits information to the cerebellum derived from sensory receptors in the muscles, joints and skin of the hind limbs. The specific aim of this proposal is to determine what information is encoded by the DSCT for transmission to the cerebellum and how the information is encoded. The experimental design incorporates random sampling of large numbers of DSCT units to determine neuron population behavior. Quantitative data analysis is based on information theory. Principal component analysis, statistical correlations and a database management system, developed specifically for the purpose, designed to allow repeated reexamination of experimental data and protocols with different working hypotheses in a systematic and ordered manner that minimizes the need for experimental animals.

拟议的研究是一个深入的计划 背脊椎区（DSCT）的神经生理研究 在猫里。 该程序的长期目标是 确定感觉受体在控制中的作用 运动和姿势。 DSCT是传输的途径 信息来自从感觉受体中得出的小脑 后肢的肌肉，关节和皮肤。 特定目的的 该建议是确定由 DSCT用于传输到小脑以及信息的方式 编码。 实验设计包含大型的随机抽样 DSCT单位的数量以确定神经元人口行为。 定量数据分析基于信息理论。 主成分分析，统计相关性和A 专为目的而开发的数据库管理系统， 旨在允许重复重新审查实验数据和 具有不同工作假设的协议在系统和 有序方式可以最大程度地减少对实验动物的需求。