PROCESSING OF INFORMATION BY THE VESTIBULOSPINAL SYSTEM

前庭脊髓系统的信息处理

• 批准号: 3409956
• 负责人: ROBERT H SCHOR
• 金额: $ 13.48万
• 依托单位: EYE AND EAR INSTITUTE OF PITTSBURGH
• 依托单位国家: 美国
• 财政年份: 1986
• 资助国家: 美国
• 起止时间: 1986-09-01 至 1993-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3409956
• 关键词: afferent nerve; antidromic impulse; cats; cerebellum; electrostimulus; evoked potentials; head movements; histology; neural information processing; neural plasticity; neuromuscular transmission; otocyst /otolith; posture; proprioception /kinesthesia; receptor; reticulospinal tract; sequential perception; spinal nerves; spinal reflex; stimulus /response; vestibular apparatus; vestibular nuclei; vestibular pathway; vestibuloocular reflex

The vestibular system, whose sensory signals originate in the labyrinth of the inner ear, plays an important role in the maintenance of normal posture. This research is designed to explore (a) how, during normal head movements, the various sensory signals coming from the labyrinth encode the spatial and temporal properties of the head movement, (b) how these signals are combined and processed by neurons in the brainstem vestibular nuclei, (c) with information is sent to various spinal motor pools to produce coordinated reflexes (for example, signals to the neck to maintain head orientation, signals to the limbs to maintain erect posture), and (d) how this information is integrated with other sensory and motor information in the balance control system. These experiments will employ the cat animal model, as much has already been learned about the neural pathways of importance in this system. Recordings will be made from single identified neurons at various levels (e.g. vestibular nerve, vestibular and other brainstem relay nuclei). Responses to controlled three- dimensional movements of the animal will permit an identification of the types of vestibular input present. Experiments are designed to study the interaction of the vestibular signals from the semicircular canals and the gravity-sensing otolith organs, the interaction between vestibular and other sensory systems, and the neural processing mechanisms which produce the observed transformed signals.

前庭系统，其感官信号起源于 内耳的迷宫，在 维持正常姿势。 这项研究旨在 探索（a）在正常的头部移动期间如何各种感觉 来自迷宫的信号编码空间和时间 头部运动的属性，（b）如何将这些信号组合在一起 并由脑干前庭核中的神经元处理，（c） 信息被发送到各种脊柱电动池以生产 协调的反射（例如，脖子的信号维护 头部方向，四肢信号以保持直立的姿势）， （d）如何将此信息与其他感官集成在一起 平衡控制系统中的电机信息。 这些实验将采用猫动物模型，因为 已经了解了重要的神经通路 这个系统。 录音将由单个确定的 各级神经元（例如前庭神经，前庭和 其他脑干继电器核）。 对受控的三响应 动物的尺寸运动将允许识别 存在的前庭输入类型。 设计实验 研究前庭信号的相互作用 半圆形管和重力敏感的耳石器官， 前庭和其他感觉系统之间的相互作用，以及 产生观察到的转化的神经加工机制 信号。